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Literature DB >> 24583801

Is there clinical value to prognostic signatures in early-stage NSCLC?

Paul A Bunn¹, Fred R Hirsch, Dara L Aisner.

Abstract

pAMPK and pmTOR favorably predicted outcome in early non-small cell lung cancer (NSCLC). The differences were small. Phosphoprotein lability makes routine clinical use and validation difficult. Protein immunohistochemistry is unlikely to be clinically useful, and numerous efforts to create predictive models to select resected patients for therapy have been unsuccessful. ©2014 AACR.

Entities: Chemical Disease Gene Species

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Year: 2014 PMID： 24583801 PMCID： PMC3998101 DOI： 10.1158/1078-0432.CCR-13-3387

Source DB: PubMed Journal: Clin Cancer Res ISSN： 1078-0432 Impact factor: 12.531

16 in total

1. A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies.

Authors: Johannes R Kratz; Jianxing He; Stephen K Van Den Eeden; Zhi-Hua Zhu; Wen Gao; Patrick T Pham; Michael S Mulvihill; Fatemeh Ziaei; Huanrong Zhang; Bo Su; Xiuyi Zhi; Charles P Quesenberry; Laurel A Habel; Qiuhua Deng; Zongfei Wang; Jiangfen Zhou; Huiling Li; Mei-Chun Huang; Che-Chung Yeh; Mark R Segal; M Roshni Ray; Kirk D Jones; Dan J Raz; Zhidong Xu; Thierry M Jahan; David Berryman; Biao He; Michael J Mann; David M Jablons
Journal: Lancet Date: 2012-01-27 Impact factor: 79.321

2. Prognostic gene signatures for non-small-cell lung cancer.

Authors: Paul C Boutros; Suzanne K Lau; Melania Pintilie; Ni Liu; Frances A Shepherd; Sandy D Der; Ming-Sound Tsao; Linda Z Penn; Igor Jurisica
Journal: Proc Natl Acad Sci U S A Date: 2009-02-05 Impact factor: 11.205

3. Retraction: A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer. N Engl J Med 2006;355:570-80.

Authors: Anil Potti; Sayan Mukherjee; Rebecca Petersen; Holly K Dressman; Andrea Bild; Jason Koontz; Robert Kratzke; Mark A Watson; Michael Kelley; Geoffrey S Ginsburg; Mike West; David H Harpole; Joseph R Nevins
Journal: N Engl J Med Date: 2011-03-02 Impact factor: 91.245

4. A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer.

5. A five-gene and corresponding protein signature for stage-I lung adenocarcinoma prognosis.

Authors: Humam Kadara; Carmen Behrens; Ping Yuan; Luisa Solis; Diane Liu; Xuemin Gu; John D Minna; J Jack Lee; Edward Kim; Waun-Ki Hong; Ignacio I Wistuba; Reuben Lotan
Journal: Clin Cancer Res Date: 2010-12-16 Impact factor: 12.531

6. Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer.

Authors: Zhibin Hu; Xi Chen; Yang Zhao; Tian Tian; Guangfu Jin; Yongqian Shu; Yijiang Chen; Lin Xu; Ke Zen; Chenyu Zhang; Hongbing Shen
Journal: J Clin Oncol Date: 2010-03-01 Impact factor: 44.544

7. Prognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer.

Authors: Chang-Qi Zhu; Keyue Ding; Dan Strumpf; Barbara A Weir; Matthew Meyerson; Nathan Pennell; Roman K Thomas; Katsuhiko Naoki; Christine Ladd-Acosta; Ni Liu; Melania Pintilie; Sandy Der; Lesley Seymour; Igor Jurisica; Frances A Shepherd; Ming-Sound Tsao
Journal: J Clin Oncol Date: 2010-09-07 Impact factor: 44.544

8. Prediction of survival in resected non-small cell lung cancer using a protein expression-based risk model: implications for personalized chemoprevention and therapy.

Authors: Kathryn A Gold; Edward S Kim; Diane D Liu; Ping Yuan; Carmen Behrens; Luisa M Solis; Humam Kadara; David C Rice; Ignacio I Wistuba; Stephen G Swisher; Wayne L Hofstetter; J Jack Lee; Waun K Hong
Journal: Clin Cancer Res Date: 2013-12-23 Impact factor: 12.531

9. Confirmation of gene expression-based prediction of survival in non-small cell lung cancer.

Authors: Nancy L Guo; Ying-Wooi Wan; Kursad Tosun; Hong Lin; Zola Msiska; Daniel C Flynn; Scot C Remick; Val Vallyathan; Afshin Dowlati; Xianglin Shi; Vincent Castranova; David G Beer; Yong Qian
Journal: Clin Cancer Res Date: 2008-12-15 Impact factor: 12.531

10. Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study.

Authors: Kerby Shedden; Jeremy M G Taylor; Steven A Enkemann; Ming-Sound Tsao; Timothy J Yeatman; William L Gerald; Steven Eschrich; Igor Jurisica; Thomas J Giordano; David E Misek; Andrew C Chang; Chang Qi Zhu; Daniel Strumpf; Samir Hanash; Frances A Shepherd; Keyue Ding; Lesley Seymour; Katsuhiko Naoki; Nathan Pennell; Barbara Weir; Roel Verhaak; Christine Ladd-Acosta; Todd Golub; Michael Gruidl; Anupama Sharma; Janos Szoke; Maureen Zakowski; Valerie Rusch; Mark Kris; Agnes Viale; Noriko Motoi; William Travis; Barbara Conley; Venkatraman E Seshan; Matthew Meyerson; Rork Kuick; Kevin K Dobbin; Tracy Lively; James W Jacobson; David G Beer
Journal: Nat Med Date: 2008-07-20 Impact factor: 53.440

3 in total