OBJECTIVES: To identify the prevalence and risk factors in the development of Neurogenic Heterotopic Ossification (NHO) in traumatic brain and spinal cord injured patients admitted to specialised units. METHODS: An audit protocol was used to gather all clinically relevant data, in specific patient groups, relating to the prevalence of NHO, and was statistically analysed to identify traumatic brain injury (TBI) and traumatic spinal cord injury (TSCI) patients at high risk of developing NHO. RESULTS: 262 TBI and 151 TSCI patients were identified. NHO was diagnosed in 10 and 16 patients with TBI and TSCI, respectively; 18 clinically relevant characteristics were analysed for association with NHO in these patient groups. The only common variables associated with NHO in both neurological conditions were deep vein thrombosis and/or pulmonary emboli (DVT/PE). CONCLUSIONS: The prevalence of NHO in TBI patients is less than one-third of that found in TSCI patients, ~4% and 11%, respectively. This study also suggests that the risk factors associated with NHO in TBI patients are distinct from those identified as risk factors in TSCI patients.
OBJECTIVES: To identify the prevalence and risk factors in the development of Neurogenic Heterotopic Ossification (NHO) in traumatic brain and spinal cord injured patients admitted to specialised units. METHODS: An audit protocol was used to gather all clinically relevant data, in specific patient groups, relating to the prevalence of NHO, and was statistically analysed to identify traumatic brain injury (TBI) and traumatic spinal cord injury (TSCI) patients at high risk of developing NHO. RESULTS: 262 TBI and 151 TSCIpatients were identified. NHO was diagnosed in 10 and 16 patients with TBI and TSCI, respectively; 18 clinically relevant characteristics were analysed for association with NHO in these patient groups. The only common variables associated with NHO in both neurological conditions were deep vein thrombosis and/or pulmonary emboli (DVT/PE). CONCLUSIONS: The prevalence of NHO in TBIpatients is less than one-third of that found in TSCIpatients, ~4% and 11%, respectively. This study also suggests that the risk factors associated with NHO in TBIpatients are distinct from those identified as risk factors in TSCIpatients.
Authors: C B Baunsgaard; H S Chhabra; L A Harvey; G Savic; S A Sisto; F Qureshi; G Sachdev; M Saif; R Sharawat; J Yeomans; F Biering-Sørensen Journal: Spinal Cord Date: 2016-05-03 Impact factor: 2.772
Authors: David McKean; Sarim Ather; Amar Gandhi; Talia Hubble; Maurizio Belci; Simone Tiberti; Joseph Papanikitas; Sarah Yanny; Deborah King; Richard Hughes; Thomas Meagher; Luis Lopez de Heredria Journal: Spinal Cord Date: 2020-09-01 Impact factor: 2.772
Authors: T E Robinson; N M Eisenstein; S C Cox; R J A Moakes; A M Thompson; Z Ahmed; E A B Hughes; L J Hill; S A Stapley; L M Grover Journal: Mater Today Bio Date: 2020-06-02
Authors: Kylie A Alexander; Hsu-Wen Tseng; Whitney Fleming; Beulah Jose; Marjorie Salga; Irina Kulina; Susan M Millard; Allison R Pettit; François Genêt; Jean-Pierre Levesque Journal: Front Immunol Date: 2019-03-07 Impact factor: 7.561