Bharat Sharma1, Abhijeet Saha2, N K Dubey1, Kanika Kapoor1, Vinita Vijay Batra3, Ashish Datt Upadhayay4. 1. Division of Pediatric Nephrology, Department of Pediatrics, Postgraduate Institute of Medical Education & Research, Dr Ram Manohar Lohia Hospital, New Delhi, India. 2. Division of Pediatric Nephrology, Department of Pediatrics, Postgraduate Institute of Medical Education & Research, Dr Ram Manohar Lohia Hospital, New Delhi, India. Electronic address: drabhijeetsaha@yahoo.com. 3. Department of Pathology, GB Pant Hospital, New Delhi, India. 4. Department of Biostatistics, AIIMS, New Delhi, India.
Abstract
BACKGROUND: Impaired endothelial function is the initial step in atherogenesis, which is largely responsible for ischaemic heart disease and thrombotic strokes decades later. METHODS: Fourty two children with first episode nephrotic syndrome (FENS) aged 1-16 years and 40 controls were enrolled. Soluble thrombomodulin (sTM), tissue plasminogen activator (t-PA), plasminogen activator inhibitor -1 (PAI-1) and von-willebrand factor (vWF) levels were measured in plasma in FENS, at 12 weeks of drug induced remission and in steroid resistant nephrotic syndrome (SRNS) patients at diagnosis. RESULTS: PAI-1, sTM, vWF and t-PA were significantly raised at the onset of nephrotic syndrome (p<0.0001). All the markers had a fall after 12 weeks of steroid treatment, but were still raised. Children with SRNS had higher levels of sTM, tPA, vWF as compared to infrequent relapsers, at onset and at 4 weeks of steroid treatment. CONCLUSION: Children with idiopathic nephrotic syndrome have endothelial dysfunction which is largely dependent upon disease activity.
BACKGROUND: Impaired endothelial function is the initial step in atherogenesis, which is largely responsible for ischaemic heart disease and thrombotic strokes decades later. METHODS: Fourty two children with first episode nephrotic syndrome (FENS) aged 1-16 years and 40 controls were enrolled. Soluble thrombomodulin (sTM), tissue plasminogen activator (t-PA), plasminogen activator inhibitor -1 (PAI-1) and von-willebrand factor (vWF) levels were measured in plasma in FENS, at 12 weeks of drug induced remission and in steroid resistant nephrotic syndrome (SRNS) patients at diagnosis. RESULTS:PAI-1, sTM, vWF and t-PA were significantly raised at the onset of nephrotic syndrome (p<0.0001). All the markers had a fall after 12 weeks of steroid treatment, but were still raised. Children with SRNS had higher levels of sTM, tPA, vWF as compared to infrequent relapsers, at onset and at 4 weeks of steroid treatment. CONCLUSION:Children with idiopathic nephrotic syndrome have endothelial dysfunction which is largely dependent upon disease activity.
Authors: Colin Bauer; Federica Piani; Mindy Banks; Flor A Ordoñez; Carmen de Lucas-Collantes; Kaori Oshima; Eric P Schmidt; Igor Zakharevich; Alfons Segarra; Cristina Martinez; Carlos Roncal-Jimenez; Simon C Satchell; Petter Bjornstad; Marshall Scott Lucia; Judith Blaine; Joshua M Thurman; Richard J Johnson; Gabriel Cara-Fuentes Journal: Kidney Int Rep Date: 2021-12-16
Authors: Szymon Mućka; Martyna Miodońska; Grzegorz K Jakubiak; Monika Starzak; Grzegorz Cieślar; Agata Stanek Journal: Int J Environ Res Public Health Date: 2022-09-07 Impact factor: 4.614