| Literature DB >> 2458323 |
R J Scheper1, J W Bulte, J G Brakkee, J J Quak, E van der Schoot, A J Balm, C J Meijer, H J Broxterman, C M Kuiper, J Lankelma.
Abstract
Resistance to multiple chemotherapeutic agents is a common clinical problem in the treatment of cancer. This resistance may occur before primary therapy or be acquired during treatment. We have generated a monoclonal antibody (MAb) (JSB-I), specific for a conserved epitope on the plasma membrane 170- to 180-kDa glycoprotein, the expression of which is strongly correlated with the degree of multi-drug resistance (MDR). JSB-I strongly binds to both Chinese-hamster-derived MDR cell lines and human MDR cell lines, including cell lines derived from lung and ovary. A drug-sensitive revertant line, and the corresponding drug-sensitive parent lines, showed only weak reactivity or none at all. JSB-I reacts strongly to air-dried or acetone-fixed cells and therefore has potential value for diagnostic detection of MDR cells in human tumor samples.Entities:
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Year: 1988 PMID： 2458323 DOI： 10.1002/ijc.2910420314
Source DB: PubMed Journal: Int J Cancer ISSN： 0020-7136 Impact factor: 7.396