Chang Rae Rho1, Jin Hyung Park1, Youn-Hea Jung1, Man Soo Kim2. 1. Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. 2. Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address: mskim@catholic.ac.kr.
Abstract
PURPOSE: We report a Korean case of concomitant keratoconus and granular corneal dystrophy type II. METHODS: Case report. RESULTS: A 29-year-old man visited our clinic for a routine ocular check-up. Slit-lamp examination revealed a few well-circumscribed, greyish-white, discrete granular opacities in the central corneal stromae of both eyes. Direct sequencing of exon 4 of the BIGH3 gene revealed a heterozygous transversion from G to A in the second-nucleotide position of codon 124. In addition, a Fleischer ring and Vogt's striae were evident in the cornea. The corneal topography was suggestive of keratoconus. CONCLUSION: Granular corneal dystrophy type II can co-exist with keratoconus and should be included in the differential diagnosis.
PURPOSE: We report a Korean case of concomitant keratoconus and granular corneal dystrophy type II. METHODS: Case report. RESULTS: A 29-year-old man visited our clinic for a routine ocular check-up. Slit-lamp examination revealed a few well-circumscribed, greyish-white, discrete granular opacities in the central corneal stromae of both eyes. Direct sequencing of exon 4 of the BIGH3 gene revealed a heterozygous transversion from G to A in the second-nucleotide position of codon 124. In addition, a Fleischer ring and Vogt's striae were evident in the cornea. The corneal topography was suggestive of keratoconus. CONCLUSION:Granular corneal dystrophy type II can co-exist with keratoconus and should be included in the differential diagnosis.