Min Mu1, Song Ye2, Ming-Jie Bai3, Guo-Li Liu4, Yuan Tong4, Su-Fang Wang5, Jie Sheng6. 1. Department of Public Health, School of Medicine, Anhui University of Science and Technology, People's Republic of China. Electronic address: mumin0611@sina.com. 2. Department of Public Health, School of Medicine, Anhui University of Science and Technology, People's Republic of China. Electronic address: candymu@126.com. 3. Department of Public Health, School of Medicine, Anhui University of Science and Technology, People's Republic of China. Electronic address: mingjiebai@126.com. 4. Department of Public Health, School of Medicine, Anhui University of Science and Technology, People's Republic of China. 5. Department of Nutrition, School of Public Health, Anhui Medical University, People's Republic of China; Department of University Hospital, Anhui Medical University, People's Republic of China. Electronic address: candymu@126.com. 6. Department of Nutrition, School of Public Health, Anhui Medical University, People's Republic of China; Department of University Hospital, Anhui Medical University, People's Republic of China. Electronic address: jieshengmm@126.com.
Abstract
BACKGROUND: Previous studies suggest that birth weight is related to later risk of asthma. However, few meta-analyses have investigated these associations. Therefore, we performed a meta-analysis with different classifications to further validate the relationship between birth weight and asthma. METHODS: PubMed (1990-2013), ScienceDirect (1990-2013), EMBASE(1990-2013),EBSCO (1990-2013) and Springer (1990-2013) were searched for articles. The following MeSH terms were used: "birth weight", "fetal growth retardation", "intrauterine growth restriction", "asthma", "wheezing". RESULTS: We included 18 studies with data from a total of over 90,000 children and adults. (1) Low birth weight (<2,500g) as compared with BW>2,500g and BW=2500-4000g was associated with increased risk of asthma (Children: OR, 1.28; 95% CI, 1.09-1.50, P<0.05; OR, 1.34; 95% CI, 1.13-1.60, P<0.05, Adults: OR, 1.25; 95% CI, 1.12-1.39, P<0.05; OR, 1.25; 95% CI, 1.12-1.40, P<0.05). (2) High birth weight (>4,000g) was not associated with the risk of asthma when BW<4,000g and BW=2500-4000g were used as the reference. CONCLUSIONS: These results suggest that low birth weight (<2,500g) is associated with increased risk of asthma both in children and adults and may serve as a mediator between prenatal influences and later disease risk; but high birth weight (>4,000g) was not associated with increased risk of asthma.
BACKGROUND: Previous studies suggest that birth weight is related to later risk of asthma. However, few meta-analyses have investigated these associations. Therefore, we performed a meta-analysis with different classifications to further validate the relationship between birth weight and asthma. METHODS: PubMed (1990-2013), ScienceDirect (1990-2013), EMBASE(1990-2013),EBSCO (1990-2013) and Springer (1990-2013) were searched for articles. The following MeSH terms were used: "birth weight", "fetal growth retardation", "intrauterine growth restriction", "asthma", "wheezing". RESULTS: We included 18 studies with data from a total of over 90,000 children and adults. (1) Low birth weight (<2,500g) as compared with BW>2,500g and BW=2500-4000g was associated with increased risk of asthma (Children: OR, 1.28; 95% CI, 1.09-1.50, P<0.05; OR, 1.34; 95% CI, 1.13-1.60, P<0.05, Adults: OR, 1.25; 95% CI, 1.12-1.39, P<0.05; OR, 1.25; 95% CI, 1.12-1.40, P<0.05). (2) High birth weight (>4,000g) was not associated with the risk of asthma when BW<4,000g and BW=2500-4000g were used as the reference. CONCLUSIONS: These results suggest that low birth weight (<2,500g) is associated with increased risk of asthma both in children and adults and may serve as a mediator between prenatal influences and later disease risk; but high birth weight (>4,000g) was not associated with increased risk of asthma.
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