Literature DB >> 24582000

Activated microglia do not form functional gap junctions in vivo.

Sameh K Wasseff1, Steven S Scherer2.   

Abstract

We investigated whether microglia form gap junctions with themselves, or with astrocytes, oligodendrocytes, or neurons in vivo in normal mouse brains, and in pathological conditions that induce microglial activation - brain injury and a model of Alzheimer's disease. Although microglia are in close physical proximity to glia and neurons, they do not form functional gap junctions under these pathological conditions.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Alzheimer's disease; Astrocytes; Brain injury; Gap junctions; Microglia; Oligodendrocytes

Mesh：

Year:  2014        PMID： 24582000      PMCID： PMC4048983          DOI： 10.1016/j.jneuroim.2014.02.005

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  22 in total

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Authors:  J I Nagy; J E Rash
Journal:  Brain Res Brain Res Rev       Date:  2000-04

2.  K+ channels and the microglial respiratory burst.

Authors:  R Khanna; L Roy; X Zhu; L C Schlichter
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Review 3.  Structural and functional diversity of connexin genes in the mouse and human genome.

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4.  Four classes of intercellular channels between glial cells in the CNS.

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Journal:  J Neurosci       Date:  2004-05-05       Impact factor: 6.167

5.  Cell-specific expression of connexins and evidence of restricted gap junctional coupling between glial cells and between neurons.

Authors:  J E Rash; T Yasumura; F E Dudek; J I Nagy
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6.  Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha.

Authors:  E A Eugenín; D Eckardt; M Theis; K Willecke; M V Bennett; J C Saez
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7.  Identification of second messengers that induce expression of functional gap junctions in microglia cultured from newborn rats.

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8.  Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury.

Authors:  J M Levine
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9.  Coupling of astrocyte connexins Cx26, Cx30, Cx43 to oligodendrocyte Cx29, Cx32, Cx47: Implications from normal and connexin32 knockout mice.

Authors:  J I Nagy; A-V Ionescu; B D Lynn; J E Rash
Journal:  Glia       Date:  2003-12       Impact factor: 7.452

10.  ATP is required and advances cytokine-induced gap junction formation in microglia in vitro.

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  12 in total

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Review 2.  Connexins and pannexins: At the junction of neuro-glial homeostasis & disease.

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Review 3.  Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?

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Review 4.  Brain Disorders and Chemical Pollutants: A Gap Junction Link?

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Review 5.  Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease.

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Review 6.  Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions.

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7.  Ground state depletion microscopy as a tool for studying microglia-synapse interactions.

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Review 8.  Gap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseases.

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Review 9.  Regulation of hemichannels and gap junction channels by cytokines in antigen-presenting cells.

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10.  Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells.

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