Ping Hua1, Weiguo Liu2, Donghui Chen3, Yanyan Zhao4, Ling Chen5, Ning Zhang5, Chun Wang5, Suwan Guo5, Li Wang6, Hong Xiao7, Sheng-Han Kuo8. 1. Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, P.R. China. 2. Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, P.R. China. Electronic address: liuweiguo1111@sina.com. 3. Department of Neurology, University of Washington, School of Medicine, Washington, 98195, United States. 4. Department of Neurology, BenQ Medical Center Affiliated to Nanjing Medical University, Nanjing 210029, P.R. China. 5. Medical Psychology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, P.R. China. 6. Clinical Laboratory, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, P.R. China. 7. Institute of Scientific Research, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, P.R. China. 8. Department of Neurology, The Neurological Institute of New York, Columbia University Medical Center, NY 10032, United States. Electronic address: sk3295@columbia.edu.
Abstract
INTRODUCTION: Accumulating evidences indicate that circadian abnormalities lead to sleep disorder, neurodegenerative diseases and depression. We have reported that the polymorphisms of a clock-related gene, Tef, contributed to the risk of sleep disturbances and depression in the Parkinson disease. The objective of the present study was to examine whether the three clock genes we previously studied are associated with major depressive disorder (MDD) in the Chinese population. METHODS: 105 Subjects with MDD and 485 control subjects participated in this case-control study. Demographics, Mini-mental Status Examination (MMSE), and the Hamilton rating scale for depression (HAMD) were obtained in all subjects. Genotypes of single nucleotide polymorphisms (SNPs) of Cry1 rs2287161, Cry2 rs10838524 and Tef rs738499 were screened by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: MDD cases had a significantly higher frequency carrying the C allele and CC genotype in Cry1 rs2287161 and the T allele and TT genotype in Tef rs738499 than controls. LIMITATIONS: The sample size of MDD group was relatively small. CONCLUSIONS: The polymorphisms of Cry1 rs2287161 and Tef rs738499 are associated to MDD.
INTRODUCTION: Accumulating evidences indicate that circadian abnormalities lead to sleep disorder, neurodegenerative diseases and depression. We have reported that the polymorphisms of a clock-related gene, Tef, contributed to the risk of sleep disturbances and depression in the Parkinson disease. The objective of the present study was to examine whether the three clock genes we previously studied are associated with major depressive disorder (MDD) in the Chinese population. METHODS: 105 Subjects with MDD and 485 control subjects participated in this case-control study. Demographics, Mini-mental Status Examination (MMSE), and the Hamilton rating scale for depression (HAMD) were obtained in all subjects. Genotypes of single nucleotide polymorphisms (SNPs) of Cry1rs2287161, Cry2rs10838524 and Tefrs738499 were screened by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS:MDD cases had a significantly higher frequency carrying the C allele and CC genotype in Cry1rs2287161 and the T allele and TT genotype in Tefrs738499 than controls. LIMITATIONS: The sample size of MDD group was relatively small. CONCLUSIONS: The polymorphisms of Cry1rs2287161 and Tefrs738499 are associated to MDD.
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