Ali M Somily1, Sarah S Alsubaie2, Abdulaziz A BinSaeed3, Armen A Torchyan4, Fahad A Alzamil2, AbdulKarim I Al-Aska5, Fatimah S Al-Khattaf6, Lyla A Khalifa6, Sahar I Al-Thawadi7, Alwaleed A Alaidan7, Mohammed N Al-Ahdal7, Ahmed A Al-Qahtani7, Thomas S Murray8. 1. Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. 2. Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. 3. Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Electronic address: abinsaid@ksu.edu.sa. 4. Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia. 5. Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia. 6. Department of Infection Control, College of Medicine, King Saud University, Riyadh, Saudi Arabia. 7. Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. 8. Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT.
Abstract
BACKGROUND: Extended-spectrum β-lactamase (ESBL)-producing Klebsiella species cause worldwide problems in neonatal intensive care units (NICUs). This study aimed to determine possible risk factors for infection or colonization with ESBL-producing Klebsiella pneumoniae (ESBLKp) during an outbreak in the NICU. METHODS: A retrospective cohort study was conducted among neonates admitted to the NICU of a teaching hospital in Riyadh, Saudi Arabia, during an outbreak of ESBLKp from April to July 2008. The incidence density ratio was calculated to determine possible predictors of ESBLKp colonization or infection. RESULTS: During 2,265 person-days of follow-up of 118 neonates, 4 became infected, and 8 were colonized with ESBLKp. Univariate analyzes revealed that, among 14 neonates who were treated with vancomycin, 9 (64.3%) developed infection or colonization with ESBLKp, whereas, among 104 neonates who were not treated with vancomycin, 3 (2.9%) were affected, with an incidence density ratio of 4.22 (95% confidence interval: 1.47-5.15). Parenteral feeding and mechanical ventilation were found to be marginally significant risk factors. CONCLUSION: Treatment with vancomycin appears to be a risk factor for infection or colonization with ESBLKp in the NICU setting.
BACKGROUND: Extended-spectrum β-lactamase (ESBL)-producing Klebsiella species cause worldwide problems in neonatal intensive care units (NICUs). This study aimed to determine possible risk factors for infection or colonization with ESBL-producing Klebsiella pneumoniae (ESBLKp) during an outbreak in the NICU. METHODS: A retrospective cohort study was conducted among neonates admitted to the NICU of a teaching hospital in Riyadh, Saudi Arabia, during an outbreak of ESBLKp from April to July 2008. The incidence density ratio was calculated to determine possible predictors of ESBLKp colonization or infection. RESULTS: During 2,265 person-days of follow-up of 118 neonates, 4 became infected, and 8 were colonized with ESBLKp. Univariate analyzes revealed that, among 14 neonates who were treated with vancomycin, 9 (64.3%) developed infection or colonization with ESBLKp, whereas, among 104 neonates who were not treated with vancomycin, 3 (2.9%) were affected, with an incidence density ratio of 4.22 (95% confidence interval: 1.47-5.15). Parenteral feeding and mechanical ventilation were found to be marginally significant risk factors. CONCLUSION: Treatment with vancomycin appears to be a risk factor for infection or colonization with ESBLKp in the NICU setting.
Authors: Choon K Sim; Sara Saheb Kashaf; Apollo Stacy; Diana M Proctor; Alexandre Almeida; Nicolas Bouladoux; Mark Chen; Robert D Finn; Yasmine Belkaid; Sean Conlan; Julia A Segre Journal: Microbiome Date: 2022-03-10 Impact factor: 14.650