Literature DB >> 24580034

Characterization of QmnD3/QmnD4 for double bond formation in quartromicin biosynthesis.

Long-Fei Wu1, Hai-Yan He, Hai-Xue Pan, Li Han, Renxiao Wang, Gong-Li Tang.   

Abstract

In this work, two enzymes responsible for the biogenesis of possible [4 + 2] reaction precursors in the quartromicin biosynthetic pathway were characterized: acetylation of 1 to yield 2 was catalyzed by QmnD3, and subsequent acetic acid elimination of 2 to form double bond product 3 was catalyzed by QmnD4. Site-directed mutagenesis assay of QmnD3 and QmnD4 was investigated, and a general base-catalyzed mechanism for QmnD4 is proposed.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24580034     DOI： 10.1021/ol500111n

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

Review 1.  Natural [4 + 2]-Cyclases.

Authors:  Byung-Sun Jeon; Shao-An Wang; Mark W Ruszczycky; Hung-Wen Liu
Journal:  Chem Rev       Date:  2016-12-01       Impact factor: 60.622

Review 2.  Spirotetronate polyketides as leads in drug discovery.

Authors:  Michelle H Lacoske; Emmanuel A Theodorakis
Journal:  J Nat Prod       Date:  2014-12-01       Impact factor: 4.050

3.  Biosynthesis of versipelostatin: identification of an enzyme-catalyzed [4+2]-cycloaddition required for macrocyclization of spirotetronate-containing polyketides.

Authors:  Takuya Hashimoto; Junko Hashimoto; Kuniko Teruya; Takashi Hirano; Kazuo Shin-ya; Haruo Ikeda; Hung-wen Liu; Makoto Nishiyama; Tomohisa Kuzuyama
Journal:  J Am Chem Soc       Date:  2015-01-05       Impact factor: 15.419

Review 4.  Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides.

Authors:  Franziska Hemmerling; Frank Hahn
Journal:  Beilstein J Org Chem       Date:  2016-07-20       Impact factor: 2.883

5.  Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3'-Deoxy Nucleoside of Pacidamycins.

Authors:  Freideriki Michailidou; Chun-Wa Chung; Murray J B Brown; Andrew F Bent; James H Naismith; William J Leavens; Sean M Lynn; Sunil V Sharma; Rebecca J M Goss
Journal:  Angew Chem Int Ed Engl       Date:  2017-08-30       Impact factor: 15.336

6.  Characterization and heterologous expression of the neoabyssomicin/abyssomicin biosynthetic gene cluster from Streptomyces koyangensis SCSIO 5802.

Authors:  Jiajia Tu; Siting Li; Jiang Chen; Yongxiang Song; Shaobin Fu; Jianhua Ju; Qinglian Li
Journal:  Microb Cell Fact       Date:  2018-02-20       Impact factor: 5.328

7.  Orange, red, yellow: biosynthesis of azaphilone pigments in Monascus fungi.

Authors:  Wanping Chen; Runfa Chen; Qingpei Liu; Yi He; Kun He; Xiaoli Ding; Lijing Kang; Xiaoxiao Guo; Nana Xie; Youxiang Zhou; Yuanyuan Lu; Russell J Cox; István Molnár; Mu Li; Yanchun Shao; Fusheng Chen
Journal:  Chem Sci       Date:  2017-04-24       Impact factor: 9.825
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.