AIM: ADRB3 DNA hypermethylation was recently associated with dyslipidemia in familial hypercholesterolemia (FH). In this study, we verified whether ADRB3 DNA methylation in blood and visceral adipose tissue (VAT) was associated with obesity and its related complications. METHODS: DNA methylation levels were measured in the blood of 61 FH men, and the blood and VAT of 30 severely obese men. Common ADRB3 polymorphisms were genotyped in all subjects. RESULTS: Higher ADRB3 DNA methylation levels were significantly associated with lower low-density lipoprotein cholesterol levels (r = -0.40; p = 0.01) in FH, and with a lower waist-to-hip ratio (r = -0.55; p = 0.01) and higher blood pressure (r = 0.43; p = 0.05) in severely obese men. ADRB3 g.-843C>T and p.W64R polymorphisms were found to be strongly associated (p < 0.001) with ADRB3 DNA methylation and mRNA levels. CONCLUSION: Although further studies are needed, these results suggest that epigenetic changes at the ADRB3 gene locus might be involved in the development of obesity and its related metabolic complications.
AIM: ADRB3 DNA hypermethylation was recently associated with dyslipidemia in familial hypercholesterolemia (FH). In this study, we verified whether ADRB3 DNA methylation in blood and visceral adipose tissue (VAT) was associated with obesity and its related complications. METHODS: DNA methylation levels were measured in the blood of 61 FH men, and the blood and VAT of 30 severely obesemen. Common ADRB3 polymorphisms were genotyped in all subjects. RESULTS: Higher ADRB3 DNA methylation levels were significantly associated with lower low-density lipoprotein cholesterol levels (r = -0.40; p = 0.01) in FH, and with a lower waist-to-hip ratio (r = -0.55; p = 0.01) and higher blood pressure (r = 0.43; p = 0.05) in severely obesemen. ADRB3 g.-843C>T and p.W64R polymorphisms were found to be strongly associated (p < 0.001) with ADRB3 DNA methylation and mRNA levels. CONCLUSION: Although further studies are needed, these results suggest that epigenetic changes at the ADRB3 gene locus might be involved in the development of obesity and its related metabolic complications.
Authors: Valentina Gonzalez-Jaramillo; Eliana Portilla-Fernandez; Marija Glisic; Trudy Voortman; Wichor Bramer; Rajiv Chowdhury; Anton J M Roks; A H Jan Danser; Taulant Muka; Jana Nano; Oscar H Franco Journal: J Hum Hypertens Date: 2019-07-25 Impact factor: 3.012
Authors: Kirsi H Pietiläinen; Jaakko Kaprio; Miina Ollikainen; Khadeeja Ismail; Kristina Gervin; Anjuska Kyllönen; Antti Hakkarainen; Jesper Lundbom; Elina A Järvinen; Jennifer R Harris; Nina Lundbom; Aila Rissanen; Robert Lyle Journal: Clin Epigenetics Date: 2015-04-02 Impact factor: 6.551
Authors: Beverly S Muhlhausler; Peter L Molloy; Susan J van Dijk; Ross L Tellam; Janna L Morrison Journal: Clin Epigenetics Date: 2015-07-11 Impact factor: 6.551
Authors: Raquel Patrícia Ataíde Lima; Rayner Anderson Ferreira do Nascimento; Rafaella Cristhine Pordeus Luna; Darlene Camati Persuhn; Alexandre Sérgio da Silva; Maria da Conceição Rodrigues Gonçalves; Alessio Tony Cavalcanti de Almeida; Ronei Marcos de Moraes; Eliseu Verly Junior; Emmanuelle Fouilloux-Meugnier; Hubert Vidal; Luciano Pirola; Marciane Magnani; Naila Francis Paulo de Oliveira; Patrícia Oliveira Prada; Maria José de Carvalho Costa Journal: Clin Epigenetics Date: 2017-10-13 Impact factor: 6.551