Literature DB >> 24579090

Direct N9-arylation of purines with aryl halides.

Anders Foller Larsen1, Trond Ulven.   

Abstract

An efficient method for N-arylation of purines is reported. The N-arylation is catalysed by Cu(i) and 4,7-bis(2-hydroxyethylamino)-1,10-phenanthroline (BHPhen) in aqueous DMF or ethanol. The reaction generally proceeds with high selectivity for the N(9)-position.

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Year:  2014        PMID: 24579090     DOI: 10.1039/c3cc48642g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  1 in total

1.  Synthesis and antiplasmodial activity of purine-based C-nucleoside analogues.

Authors:  Kartikey Singh; Prince Joshi; Rohit Mahar; Pragati Baranwal; Sanjeev K Shukla; Renu Tripathi; Rama Pati Tripathi
Journal:  Medchemcomm       Date:  2018-05-29       Impact factor: 3.597

  1 in total

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