| Literature DB >> 24578297 |
Haibin Xi1, Metin Kurtoglu, Theodore J Lampidis.
Abstract
Through the eons of time, out of all possible configurations, nature has selected glucose not only as a vital source of energy to sustain life but also as the molecule who's structure supplies the appropriate elements required for a cell to grow and multiply. This understanding, at least in part, explains the profound effects that the analog of glucose, 2-deoxy-d-glucose, has been shown to have on as common and widespread diseases as cancer, viral infection, aging-related morbidity, epilepsy, and others. This review is confined to summarizing some of the salient findings of this remarkable compound as they relate mainly to cancer.Entities:
Keywords: 2-deoxy-d-glucose; apoptosis; autophagy; endoplasmic reticulum stress; glycosylation; hypoxia; viral replication
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Year: 2014 PMID: 24578297 DOI: 10.1002/iub.1251
Source DB: PubMed Journal: IUBMB Life ISSN: 1521-6543 Impact factor: 3.885