Literature DB >> 24578297

The wonders of 2-deoxy-D-glucose.

Haibin Xi1, Metin Kurtoglu, Theodore J Lampidis.   

Abstract

Through the eons of time, out of all possible configurations, nature has selected glucose not only as a vital source of energy to sustain life but also as the molecule who's structure supplies the appropriate elements required for a cell to grow and multiply. This understanding, at least in part, explains the profound effects that the analog of glucose, 2-deoxy-d-glucose, has been shown to have on as common and widespread diseases as cancer, viral infection, aging-related morbidity, epilepsy, and others. This review is confined to summarizing some of the salient findings of this remarkable compound as they relate mainly to cancer.
© 2014 International Union of Biochemistry and Molecular Biology.

Entities:  

Keywords:  2-deoxy-d-glucose; apoptosis; autophagy; endoplasmic reticulum stress; glycosylation; hypoxia; viral replication

Mesh:

Substances:

Year:  2014        PMID: 24578297     DOI: 10.1002/iub.1251

Source DB:  PubMed          Journal:  IUBMB Life        ISSN: 1521-6543            Impact factor:   3.885


  33 in total

1.  The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress.

Authors:  Morten Luhr; Maria Lyngaas Torgersen; Paula Szalai; Adnan Hashim; Andreas Brech; Judith Staerk; Nikolai Engedal
Journal:  J Biol Chem       Date:  2019-03-29       Impact factor: 5.157

2.  Glycolytic reprogramming of macrophages activated by NOD1 and TLR4 agonists: No association with proinflammatory cytokine production in normoxia.

Authors:  Nina E Murugina; Anna S Budikhina; Yulia A Dagil; Polina V Maximchik; Lyudmila S Balyasova; Vladimir V Murugin; Mikhail V Melnikov; Viktoriya S Sharova; Anna M Nikolaeva; Georgy Z Chkadua; Boris V Pinegin; Mikhail V Pashenkov
Journal:  J Biol Chem       Date:  2020-01-31       Impact factor: 5.157

3.  Transposon-mediated activation of the Escherichia coli glpFK operon is inhibited by specific DNA-binding proteins: Implications for stress-induced transposition events.

Authors:  Zhongge Zhang; Milton H Saier
Journal:  Mutat Res       Date:  2016-10-27       Impact factor: 2.433

4.  PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epidermal Keratinocytes.

Authors:  Robert B Hamanaka; Gökhan M Mutlu
Journal:  J Invest Dermatol       Date:  2017-01-17       Impact factor: 8.551

5.  Phosphatase control of 4E-BP1 phosphorylation state is central for glycolytic regulation of retinal protein synthesis.

Authors:  Thomas W Gardner; Steven F Abcouwer; Mandy K Losiewicz; Patrice E Fort
Journal:  Am J Physiol Endocrinol Metab       Date:  2015-07-21       Impact factor: 4.310

6.  Targeting energy metabolism of cancer cells: Combined administration of NCL-240 and 2-DG.

Authors:  Bhushan S Pattni; Aditi Jhaveri; Ivy Dutta; James D Baleja; Alexei Degterev; Vladimir Torchilin
Journal:  Int J Pharm       Date:  2017-08-24       Impact factor: 5.875

7.  Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells.

Authors:  Donna L Nile; Colin Rae; David J Walker; Joe Canning Waddington; Isabel Vincent; Karl Burgess; Mark N Gaze; Robert J Mairs; Anthony J Chalmers
Journal:  Cancer Metab       Date:  2021-05-19

Review 8.  Emerging trends from COVID-19 research registered in the Clinical Trials Registry - India.

Authors:  M Vishnu Vardhana Rao; Atul Juneja; Mohua Maulik; Tulsi Adhikari; Saurabh Sharma; Jyotsna Gupta; Yashmin Panchal; Neha Yadav
Journal:  Indian J Med Res       Date:  2021 Jan & Feb       Impact factor: 2.375

9.  Proteomic analysis of mitochondrial biogenesis in cardiomyocytes differentiated from human induced pluripotent stem cells.

Authors:  Sundararajan Venkatesh; Erdene Baljinnyam; Mingming Tong; Toshihide Kashihara; Lin Yan; Tong Liu; Hong Li; Lai-Hua Xie; Michinari Nakamura; Shin-Ichi Oka; Carolyn K Suzuki; Diego Fraidenraich; Junichi Sadoshima
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2020-10-28       Impact factor: 3.619

10.  Differential Glycosite Profiling-A Versatile Method to Compare Membrane Glycoproteomes.

Authors:  Malwina Michalak; Martin Simon Kalteis; Aysel Ahadova; Matthias Kloor; Mark Kriegsmann; Katharina Kriegsmann; Uwe Warnken; Dominic Helm; Jürgen Kopitz
Journal:  Molecules       Date:  2021-06-10       Impact factor: 4.411

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