| Literature DB >> 24577889 |
Yonggang Zhang1, Qingyi Jia, Qing He, Jiani Shen, Jiqiao Yang, Pei Xue, Mengmeng Ma, Rui Xu, Liang Du.
Abstract
The Glu298Asp polymorphism in the NOS3 gene has been implicated as a risk factor for prostate cancer. To date, several studies have evaluated the associations between the Glu298Asp polymorphism and prostate cancer risk; however, the results were inconclusive. The aim of the current study was to perform a meta-analysis to investigate the association between the polymorphism and the risk of prostate cancer. A total of 3,206 cases and 3,880 controls from eight case-control studies were included for data synthesis. The overall results suggested no significant association between the polymorphism and the risk of prostate cancer (OR=1.01, 95% CI=0.92-1.11, p = 0.83 for Asp/Asp+Glu/Asp vs. Glu/Glu). In the stratified analysis according to ethnicity, no significant associations were observed in Asians and Europeans. The current meta-analysis suggested that the Glu298Asp polymorphism of the NOS3 gene might not contribute to the risk of prostate cancer.Entities:
Mesh：
Substances：
Year: 2014 PMID： 24577889 DOI： 10.1007/s13277-014-1619-4
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283