Literature DB >> 24577262

[Delayed wound healing during therapy of cutaneous graft-versus-host disease with everolimus].

A Brown1, D Neumayer, Z Rafieé-Tari, T Krieg, S A Eming.   

Abstract

Graft-versus-host-disease (GvHD) is despite improvement in transplantation medicine the major cause for morbidity and mortality after allogeneic stem cell transplantation. We describe a patient with chronic cutaneous GvHD who developed massive skin ulcerations after changing the immunosuppressive therapy to a mammalian target of rapamycin (mTOR)-inhibitor.

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Year:  2014        PMID： 24577262     DOI： 10.1007/s00105-014-2762-y

Source DB:  PubMed          Journal:  Hautarzt        ISSN： 0017-8470            Impact factor:   0.751


  15 in total

1.  [Graft-versus-Host Disease (GvHD) - an update : Part 1: Pathophysiology, clinical features and classification of GvHD].

Authors:  R Travnik; M Beckers; D Wolff; E Holler; M Landthaler; S Karrer
Journal:  Hautarzt       Date:  2011-02       Impact factor: 0.751

Review 2.  Effects of immunosuppressive therapy on wound healing.

Authors:  Roshan Bootun
Journal:  Int Wound J       Date:  2012-02-24       Impact factor: 3.315

Review 3.  TOR signaling in growth and metabolism.

Authors:  Stephan Wullschleger; Robbie Loewith; Michael N Hall
Journal:  Cell       Date:  2006-02-10       Impact factor: 41.582

4.  Rapamycin (sirolimus) inhibits proliferating cell nuclear antigen expression and blocks cell cycle in the G1 phase in human keratinocyte stem cells.

Authors:  A F Javier; Z Bata-Csorgo; C N Ellis; S Kang; J J Voorhees; K D Cooper
Journal:  J Clin Invest       Date:  1997-05-01       Impact factor: 14.808

5.  Consensus conference on clinical practice in chronic graft-versus-host disease (GVHD): first-line and topical treatment of chronic GVHD.

Authors:  Daniel Wolff; Armin Gerbitz; Francis Ayuk; Alexander Kiani; Gerhard C Hildebrandt; Georgia B Vogelsang; Sharon Elad; Anita Lawitschka; Gerard Socie; Steven Z Pavletic; Ernst Holler; Hildegard Greinix
Journal:  Biol Blood Marrow Transplant       Date:  2010-06-25       Impact factor: 5.742

6.  Rapamycin-induced impaired wound healing is associated with compromised tissue lactate accumulation and extracellular matrix remodeling.

Authors:  J Weinreich; S Löb; M Löffler; I Königsrainer; D Zieker; A Königsrainer; S Coerper; S Beckert
Journal:  Eur Surg Res       Date:  2011-05-20       Impact factor: 1.745

Review 7.  [Graft-versus-host disease (GvHD) - an update. Part 2: prognosis and therapy of GvHD].

Authors:  R Travnik; M Beckers; D Wolff; E Holler; M Landthaler; S Karrer
Journal:  Hautarzt       Date:  2011-03       Impact factor: 0.751

8.  Mammalian target of rapamycin (mTOR) inhibitors slow skin carcinogenesis, but impair wound healing.

Authors:  L Feldmeyer; G F L Hofbauer; T Böni; L E French; J Hafner
Journal:  Br J Dermatol       Date:  2011-12-05       Impact factor: 9.302

9.  Sirolimus and secondary skin-cancer prevention in kidney transplantation.

Authors:  Sylvie Euvrard; Emmanuel Morelon; Lionel Rostaing; Eric Goffin; Anabelle Brocard; Isabelle Tromme; Nilufer Broeders; Veronique del Marmol; Valérie Chatelet; Anne Dompmartin; Michèle Kessler; Andreas L Serra; Günther F L Hofbauer; Claire Pouteil-Noble; Josep M Campistol; Jean Kanitakis; Adeline S Roux; Evelyne Decullier; Jacques Dantal
Journal:  N Engl J Med       Date:  2012-07-26       Impact factor: 91.245

10.  Sclerodermatous chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: incidence, predictors and outcome.

Authors:  Cristina Skert; Francesca Patriarca; Alessandra Sperotto; Michela Cerno; Carla Filì; Francesco Zaja; Raffaella Stocchi; Antonella Geromin; Daniela Damiani; Renato Fanin
Journal:  Haematologica       Date:  2006-02       Impact factor: 9.941
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  2 in total

Review 1.  New perspectives on the use of mTOR inhibitors in allogeneic haematopoietic stem cell transplantation and graft-versus-host disease.

Authors:  Mathias Lutz; Stephan Mielke
Journal:  Br J Clin Pharmacol       Date:  2016-06-22       Impact factor: 4.335

Review 2.  The regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling.

Authors:  Juan Wang; Baiping Cui; Zhongjian Chen; Xiaolei Ding
Journal:  Front Cell Dev Biol       Date:  2022-07-22
  2 in total

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