Literature DB >> 24576898

SIK2 regulates insulin secretion.

Bengt-Frederik Belgardt1, Markus Stoffel1.   

Abstract

Correct regulation of insulin secretion by the pancreas is crucial for organismal function and survival. The AMPK-related kinase SIK2 (salt-inducible kinase 2) is now shown to be stabilized in pancreatic β-cells following glucose stimulation, leading to improved systemic glucose homeostasis by regulating cellular calcium flux and insulin secretion.

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Year:  2014        PMID： 24576898     DOI： 10.1038/ncb2925

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  15 in total

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4.  Control of PKA stability and signalling by the RING ligase praja2.

Authors:  Luca Lignitto; Annalisa Carlucci; Maria Sepe; Eduard Stefan; Ornella Cuomo; Robert Nisticò; Antonella Scorziello; Claudia Savoia; Corrado Garbi; Lucio Annunziato; Antonio Feliciello
Journal:  Nat Cell Biol       Date:  2011-03-20       Impact factor: 28.824

Review 5.  The regulation and function of mammalian AMPK-related kinases.

Authors:  N J Bright; C Thornton; D Carling
Journal:  Acta Physiol (Oxf)       Date:  2009-02-19       Impact factor: 6.311

Review 6.  Selective insulin and leptin resistance in metabolic disorders.

Authors:  A Christine Könner; Jens C Brüning
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7.  Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.

Authors:  Jun-Ichi Sakamaki; Accalia Fu; Courtney Reeks; Stephen Baird; Chantal Depatie; Mufida Al Azzabi; Nabeel Bardeesy; Anne-Claude Gingras; Siu-Pok Yee; Robert A Screaton
Journal:  Nat Cell Biol       Date:  2014-03       Impact factor: 28.824

Review 8.  Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea.

Authors:  S Seino
Journal:  Diabetologia       Date:  2012-05-04       Impact factor: 10.122

Review 9.  Diabetes mellitus and the β cell: the last ten years.

Authors:  Frances M Ashcroft; Patrik Rorsman
Journal:  Cell       Date:  2012-03-16       Impact factor: 41.582

Review 10.  AMPK, insulin resistance, and the metabolic syndrome.

Authors:  Neil B Ruderman; David Carling; Marc Prentki; José M Cacicedo
Journal:  J Clin Invest       Date:  2013-07-01       Impact factor: 14.808
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  1 in total

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Journal:  J Biol Chem       Date:  2014-07-07       Impact factor: 5.157
  1 in total

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