Literature DB >> 24575368

FGF receptor antagonism does not affect adipose tissue development in nutritionally induced obesity.

Ilse Scroyen1, Christine Vranckx1, Henri Roger Lijnen1.   

Abstract

The fibroblast growth factor (FGF)-FGF receptor (FGFR) system plays a role in angiogenesis and maintenance of vascular integrity, but its potential role in adipose tissue related angiogenesis and development is still unknown. Administration of SSR, a low molecular weight inhibitor of multiple FGFRs, did not significantly affect body weight nor weight of subcutaneous or gonadal (GON) fat, as compared with pair-fed control mice. Adipocyte hypertrophy and reduced adipocyte density were only observed in GON adipose tissues of treated mice. Adipose tissue angiogenesis was not affected by SSR treatment, as normalized blood vessel density was comparable in adipose tissues of both groups. Blocking the FGF-FGFR system in vivo does not markedly affect adipose tissue development in mice with nutritionally induced obesity.

Entities:  

Keywords:  adipose tissue; angiogenesis; fibroblast growth factor; mouse model; obesity

Year:  2013        PMID： 24575368      PMCID： PMC3917932          DOI： 10.4161/adip.27233

Source DB:  PubMed          Journal:  Adipocyte        ISSN： 2162-3945            Impact factor:   4.534


  16 in total

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Journal:  J Clin Invest       Date:  2008-10       Impact factor: 14.808

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Journal:  Cancer Cell       Date:  2013-04-15       Impact factor: 31.743

3.  CD36 promotes adipocyte differentiation and adipogenesis.

Authors:  Valerie Christiaens; Matthias Van Hul; H Roger Lijnen; Ilse Scroyen
Journal:  Biochim Biophys Acta       Date:  2012-04-06

4.  Chronic alcohol consumption disrupted cholesterol homeostasis in rats: down-regulation of low-density lipoprotein receptor and enhancement of cholesterol biosynthesis pathway in the liver.

Authors:  Zhigang Wang; Tong Yao; Zhenyuan Song
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5.  De novo adipogenesis in mice at the site of injection of basement membrane and basic fibroblast growth factor.

Authors:  N Kawaguchi; K Toriyama; E Nicodemou-Lena; K Inou; S Torii; Y Kitagawa
Journal:  Proc Natl Acad Sci U S A       Date:  1998-02-03       Impact factor: 11.205

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Authors:  Haijun D Sun; Maria Malabunga; James R Tonra; Roberto DiRenzo; Francine E Carrick; Huiyuan Zheng; Hans-Rudolf Berthoud; Owen P McGuinness; Juqun Shen; Peter Bohlen; Rudolph L Leibel; Paul Kussie
Journal:  Am J Physiol Endocrinol Metab       Date:  2006-11-28       Impact factor: 4.310

7.  Modulation of angiogenesis during adipose tissue development in murine models of obesity.

Authors:  Gabor Voros; Erik Maquoi; Diego Demeulemeester; Natalie Clerx; Désiré Collen; H Roger Lijnen
Journal:  Endocrinology       Date:  2005-07-14       Impact factor: 4.736

8.  Adipose tissue mass can be regulated through the vasculature.

Authors:  Maria A Rupnick; Dipak Panigrahy; Chen-Yu Zhang; Susan M Dallabrida; Bradford B Lowell; Robert Langer; M Judah Folkman
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-29       Impact factor: 11.205

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Authors:  Françoise Bono; Frederik De Smet; Corentin Herbert; Katrien De Bock; Maria Georgiadou; Pierre Fons; Marc Tjwa; Chantal Alcouffe; Annelii Ny; Marc Bianciotto; Bart Jonckx; Masahiro Murakami; Anthony A Lanahan; Christof Michielsen; David Sibrac; Frédérique Dol-Gleizes; Massimiliano Mazzone; Serena Zacchigna; Jean-Pascal Herault; Christian Fischer; Patrice Rigon; Carmen Ruiz de Almodovar; Filip Claes; Isabelle Blanc; Koen Poesen; Jie Zhang; Inmaculada Segura; Geneviève Gueguen; Marie-Françoise Bordes; Diether Lambrechts; Roselyne Broussy; Marlies van de Wouwer; Corinne Michaux; Toru Shimada; Isabelle Jean; Silvia Blacher; Agnès Noel; Patrick Motte; Eran Rom; Jean-Marie Rakic; Susumu Katsuma; Paul Schaeffer; Avner Yayon; Ann Van Schepdael; Harald Schwalbe; Francesco Luigi Gervasio; Geert Carmeliet; Jef Rozensky; Mieke Dewerchin; Michael Simons; Arthur Christopoulos; Jean-Marc Herbert; Peter Carmeliet
Journal:  Cancer Cell       Date:  2013-04-15       Impact factor: 31.743

10.  Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis.

Authors:  Dai Fukumura; Akira Ushiyama; Dan G Duda; Lei Xu; Joshua Tam; V Krishna; K Chatterjee; Igor Garkavtsev; Rakesh K Jain
Journal:  Circ Res       Date:  2003-10-02       Impact factor: 17.367
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Journal:  Lipids Health Dis       Date:  2014-08-16       Impact factor: 3.876
  1 in total

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