Literature DB >> 24574769

Cysteinyl leukotrienes and their receptors: bridging inflammation and colorectal cancer.

Sayeh Savari1, Katyayni Vinnakota1, Yuan Zhang1, Anita Sjölander1.   

Abstract

Long-standing inflammation has emerged as a hallmark of neoplastic transformation of epithelial cells and may be a limiting factor of successful conventional tumor therapies. A complex milieu composed of distinct stromal and immune cells, soluble factors and inflammatory mediators plays a crucial role in supporting and promoting various types of cancers. An augmented inflammatory response can predispose a patient to colorectal cancer (CRC). Common risk factors associated with CRC development include diet and lifestyle, altered intestinal microbiota and commensals, and chronic inflammatory bowel diseases. Cysteinyl leukotrienes are potent inflammatory metabolites synthesized from arachidonic acid and have a broad range of functions involved in the etiology of various pathologies. This review discusses the important role of cysteinyl leukotriene signaling in linking inflammation and CRC.

Entities:  

Keywords:  Colorectal cancer; CysLT1R; CysLT2R; Cysteinyl leukotrienes; Eicosanoids; Inflammation

Mesh：

Substances：

Year:  2014        PMID： 24574769      PMCID： PMC3921548          DOI： 10.3748/wjg.v20.i4.968

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  110 in total

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