Literature DB >> 24574737

Impairment of ghrelin synthesis in Helicobacter pylori-colonized stomach: new clues for the pathogenesis of H. pylori-related gastric inflammation.

Omero Alessandro Paoluzi1, Del Vecchio Giovanna Blanco1, Roberta Caruso1, Ivan Monteleone1, Giovanni Monteleone1, Francesco Pallone1.   

Abstract

Ghrelin, the ligand of growth hormone secretagogue receptor 1a, takes part in several functions of the digestive system, including regulation of appetite, energy homeostasis, gastric acid secretion and motility. Ghrelin has also immunoregulatory properties and is supposed to inhibit some inflammatory pathways that can mediate gastric damage. Interestingly, ghrelin synthesis is reduced in the gastric mucosa of patients with Helicobacter pylori (H. pylori) infection, a worldwide condition inducing a T helper (Th)1/Th17 cell response-driven gastritis, which may evolve towards gastric atrophy and cancer. In this article, we review the available data on the expression of ghrelin in H. pylori infection and discuss how the defective ghrelin synthesis may contribute to sustain the ongoing inflammatory response in this disease.

Entities:  

Keywords:  Gastritis; Ghrelin; Helicobacter pylori; T helper 1 cells

Mesh：

Substances：

Year:  2014        PMID： 24574737      PMCID： PMC3921473          DOI： 10.3748/wjg.v20.i3.639

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  108 in total

1.  Low plasma ghrelin levels in patients with Helicobacter pylori-associated gastritis.

Authors:  Hajime Isomoto; Masamitsu Nakazato; Hiroaki Ueno; Yukari Date; Yoshito Nishi; Hiroshi Mukae; Yohei Mizuta; Akira Ohtsuru; Shunichi Yamashita; Shigeru Kohno
Journal:  Am J Med       Date:  2004-09-15       Impact factor: 4.965

2.  Ghrelin protects against ethanol-induced gastric ulcers in rats: studies on the mechanisms of action.

Authors:  V Sibilia; G Rindi; F Pagani; D Rapetti; V Locatelli; A Torsello; N Campanini; R Deghenghi; C Netti
Journal:  Endocrinology       Date:  2003-01       Impact factor: 4.736

3.  Ghrelin induces gastric cancer cell proliferation, migration, and invasion through GHS-R/NF-κB signaling pathway.

Authors:  Chuang Tian; Lianhai Zhang; Daohu Hu; Jiafu Ji
Journal:  Mol Cell Biochem       Date:  2013-06-27       Impact factor: 3.396

4.  Circulating ghrelin levels as function of gender, pubertal status and adiposity in childhood.

Authors:  S Bellone; A Rapa; D Vivenza; N Castellino; A Petri; J Bellone; E Me; F Broglio; F Prodam; E Ghigo; G Bona
Journal:  J Endocrinol Invest       Date:  2002-05       Impact factor: 4.256

5.  Long-term effect of Helicobacter pylori eradication on quality of life, body mass index, and newly developed diseases in Japanese patients with peptic ulcer disease.

Authors:  Yasuhiro Fujiwara; Kazuhide Higuchi; Usama A Arafa; Toshiyuki Uchida; Kazunari Tominaga; Toshio Watanabe; Tetsuo Arakawa
Journal:  Hepatogastroenterology       Date:  2002 Sep-Oct

6.  Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation.

Authors:  Xiangbin Xu; Bong Sook Jhun; Chang Hoon Ha; Zheng-Gen Jin
Journal:  Endocrinology       Date:  2008-05-01       Impact factor: 4.736

7.  Ghrelin acts in the central nervous system to stimulate gastric acid secretion.

Authors:  Y Date; M Nakazato; N Murakami; M Kojima; K Kangawa; S Matsukura
Journal:  Biochem Biophys Res Commun       Date:  2001-01-26       Impact factor: 3.575

8.  Ghrelin-a new gastroprotective factor in gastric mucosa.

Authors:  P C Konturek; T Brzozowski; R Pajdo; A Nikiforuk; S Kwiecien; I Harsch; D Drozdowicz; E G Hahn; S J Konturek
Journal:  J Physiol Pharmacol       Date:  2004-06       Impact factor: 3.011

9.  Testosterone is a strong correlate of ghrelin levels in men and postmenopausal women.

Authors:  Yona Greenman; Vanessa Rouach; Rona Limor; Susan Gilad; Naftali Stern
Journal:  Neuroendocrinology       Date:  2008-08-28       Impact factor: 4.914

Review 10.  Ghrelin and gastric acid secretion.

Authors:  Koji Yakabi; Junichi Kawashima; Shingo Kato
Journal:  World J Gastroenterol       Date:  2008-11-07       Impact factor: 5.742
View more
  11 in total

Review 1.  Role of Helicobacter pylori infection in pathogenesis of gastric carcinoma.

Authors:  Rong-Guang Zhang; Guang-Cai Duan; Qing-Tang Fan; Shuai-Yin Chen
Journal:  World J Gastrointest Pathophysiol       Date:  2016-02-15

2.  Helicobacter pylori infection and serum leptin, obestatin, and ghrelin levels in Mexican schoolchildren.

Authors:  Carolina Romo-González; Eugenia Mendoza; Robertino M Mera; Rafael Coria-Jiménez; Patricia Chico-Aldama; Rita Gomez-Diaz; Ximena Duque
Journal:  Pediatr Res       Date:  2017-06-14       Impact factor: 3.756

Review 3.  The Role of H. pylori CagA in Regulating Hormones of Functional Dyspepsia Patients.

Authors:  Wang-Ping Meng; Zhong-Qiong Wang; Jia-Qi Deng; Yi Liu; Ming-Ming Deng; Mu-Han Lü
Journal:  Gastroenterol Res Pract       Date:  2016-10-20       Impact factor: 2.260

Review 4.  Molecular mimicry in Helicobacter pylori infections.

Authors:  Magdalena Chmiela; Weronika Gonciarz
Journal:  World J Gastroenterol       Date:  2017-06-14       Impact factor: 5.742

5.  Prognostic Significance of Preoperative and Postoperative Plasma Levels of Ghrelin in Gastric Cancer: 3-Year Survival Study.

Authors:  Saeed Soleyman-Jahi; Afshin Abdirad; Amir Afraz Fallah; Sevil Ghasemi; Fatemeh Sadeghi; Reza Heidari; Habibollah Mahmoodzadeh; Kazem Zendehdel
Journal:  Clin Transl Gastroenterol       Date:  2017-01-05       Impact factor: 4.488

6.  Assessing the Relationship between Helicobacter pylori and Chronic Kidney Disease.

Authors:  Koichi Hata; Teruhide Koyama; Etsuko Ozaki; Nagato Kuriyama; Shigeto Mizuno; Daisuke Matsui; Isao Watanabe; Ritei Uehara; Yoshiyuki Watanabe
Journal:  Healthcare (Basel)       Date:  2021-02-03

7.  Long-term effect of the eradication of Helicobacter pylori on the hemoglobin A1c in type 2 diabetes or prediabetes patients.

Authors:  Won Seok Kim; Yonghoon Choi; Nayoung Kim; Seon Hee Lim; Gitark Noh; Ki Wook Kim; Jaehyung Park; Hyeongho Jo; Hyuk Yoon; Cheol Min Shin; Young Soo Park; Dong Ho Lee
Journal:  Korean J Intern Med       Date:  2022-01-07       Impact factor: 3.165

8.  Serum ghrelin and esophageal and gastric cancer in two cohorts in China.

Authors:  Natalie R Pritchett; Marlena Maziarz; Xiao-Ou Shu; Farin Kamangar; Sanford M Dawsey; Jin-Hu Fan; Bu-Tian Ji; Yu-Tang Gao; Yong-Bing Xiang; You-Lin Qiao; Honglan Li; Gong Yang; Shao-Ming Wang; Frank Z Stanczyk; Wong-Ho Chow; Hormuzd A Katki; Wei Zheng; Qing Lan; Neal D Freedman; Nat Rothman; Christian C Abnet; Gwen Murphy
Journal:  Int J Cancer       Date:  2019-08-12       Impact factor: 7.316

9.  Influence of Helicobacter pylori Infection on Metabolic Syndrome in Old Chinese People.

Authors:  Wen Yang; Cunfu Xuan
Journal:  Gastroenterol Res Pract       Date:  2016-06-27       Impact factor: 2.260

10.  Polymorphisms at Locus 4p14 of Toll-Like Receptors TLR-1 and TLR-10 Confer Susceptibility to Gastric Carcinoma in Helicobacter pylori Infection.

Authors:  M Ravishankar Ram; Khean Lee Goh; Alex Hwong Ruey Leow; Bee Hoon Poh; Mun Fai Loke; Richard Harrison; Esaki M Shankar; Jamuna Vadivelu
Journal:  PLoS One       Date:  2015-11-11       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.