Literature DB >> 24573999

Association between ACE I/D polymorphism and pulmonary tuberculosis in Chinese population.

Yonggang Zhang1, Xiaobo Li, Zhangjun Wu, Hong Fan.   

Abstract

Tuberculosis (TB) remains a global public health problem worldwide. The objective of the current study is to investigate the possible association of ACE I/D polymorphism with pulmonary TB (PTB) for Chinese in Sichuan province. Three hundred eighty-six PTB patients and 398 healthy controls were genotyped to analyze the I/D polymorphism using PCR method. The results showed that the I/D polymorphism was not associated with susceptibility to PTB for Chinese (D vs. I: OR 1.03, 95% CI 0.84-1.26, and P=0.77; DD vs. II+DI: OR 1.09, 95% CI 0.73-1.63, and P=0.68; DD+DI vs. II: OR 1.00, 95% CI 0.74-1.33, and P=0.98). The I/D polymorphism in the ACE gene may not a risk factor for PTB in Chinese.

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Year:  2014        PMID： 24573999     DOI： 10.1007/s11033-014-3178-6

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  9 in total

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  9 in total

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