Literature DB >> 24573860

Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor -induced cell migration.

Xiaowei Gong1, Jie Wei, Yusheng Li, Weiwei Cheng, Peng Deng, Yong Jiang.   

Abstract

The aim of this study was to investigate the role of p38 mitogen-activated protein kinase (MAPK) in cell migration induced by platelet-derived growth factor (PDGF). Western blot was performed to detect the phosphorylation of p38 in NIH3T3 cells treated with PDGF. A Transwell cell migration system was used to determine the effects of PDGF treatment on the migration of NIH3T3 cells and the influence of p38 deficiency on this process in a p38 gene knockout (p38(-/-)) mouse embryonic fibroblast cell line. On the stimulation of PDGF, the migration of NIH3T3 cells was significantly increased (P < 0.001) compared to the control and p38 MAP kinase was simultaneously phosphorylated. Furthermore, the PDGF-induced cell migration was significantly blocked in p38 gene knockout (p38(-/-)) mouse embryonic fibroblasts (MEFs) (P < 0.001) as compared with the wild type cells (p38(+/+)). p38 MAPK plays an important role in the regulation of cell migration induced by PDGF.

Entities:  

Year:  2007        PMID： 24573860     DOI： 10.1007/s11684-007-0047-x

Source DB:  PubMed          Journal:  Front Med China        ISSN： 1673-7342


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