Literature DB >> 24573748

MicroRNA-based therapy in cardiology.

J Fiedler1, S Batkai, T Thum.   

Abstract

The pathogenic role of noncoding microRNA (miR, miRNA) has been demonstrated for several disease conditions in the heart. The underlying molecular mechanisms have been deciphered for numerous miRs that are deregulated as a result of cardiac stress. Innovative therapeutic strategies based on antifibrotic, antihypertrophic, or proangiogenic effects of miRNAs are being currently developed to improve the function of the failing heart. Identifying a safe and efficient miR-based strategy remains challenging, yet these novel approaches offer enormous potential for the treatments for heart failure. In this review we highlight the latest development in the cardiac miRNA field.

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Year:  2014        PMID： 24573748     DOI： 10.1007/s00059-013-4047-0

Source DB:  PubMed          Journal:  Herz        ISSN： 0340-9937            Impact factor:   1.443


  38 in total

Review 1.  Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia.

Authors:  Razi Khan; Richard Sheppard
Journal:  Immunology       Date:  2006-05       Impact factor: 7.397

2.  MicroRNA-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the FBJ osteosarcoma oncogene/transforming growth factor-β1 pathway.

Authors:  Zhenwei Pan; Xuelin Sun; Hongli Shan; Ning Wang; Jinghao Wang; Jinshuai Ren; Shuya Feng; Liangjun Xie; Chunying Lu; Ye Yuan; Yang Zhang; Ying Wang; Yanjie Lu; Baofeng Yang
Journal:  Circulation       Date:  2012-07-18       Impact factor: 29.690

3.  Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

Authors:  S Izumo; B Nadal-Ginard; V Mahdavi
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

4.  Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function.

Authors:  Bianca C Bernardo; Xiao-Ming Gao; Catherine E Winbanks; Esther J H Boey; Yow Keat Tham; Helen Kiriazis; Paul Gregorevic; Susanna Obad; Sakari Kauppinen; Xiao-Jun Du; Ruby C Y Lin; Julie R McMullen
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-09       Impact factor: 11.205

Review 5.  Cardiac remodeling--concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling.

Authors:  J N Cohn; R Ferrari; N Sharpe
Journal:  J Am Coll Cardiol       Date:  2000-03-01       Impact factor: 24.094

6.  Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure.

Authors:  Prakash K Rao; Yumiko Toyama; H Rosaria Chiang; Sumeet Gupta; Michael Bauer; Rostislav Medvid; Ferenc Reinhardt; Ronglih Liao; Monty Krieger; Rudolf Jaenisch; Harvey F Lodish; Robert Blelloch
Journal:  Circ Res       Date:  2009-08-13       Impact factor: 17.367

7.  Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure.

Authors:  Ellen Dirkx; Monika M Gladka; Leonne E Philippen; Anne-Sophie Armand; Virginie Kinet; Stefanos Leptidis; Hamid El Azzouzi; Kanita Salic; Meriem Bourajjaj; Gustavo J J da Silva; Servé Olieslagers; Roel van der Nagel; Roel de Weger; Nicole Bitsch; Natasja Kisters; Sandrine Seyen; Yuka Morikawa; Christophe Chanoine; Stephane Heymans; Paul G A Volders; Thomas Thum; Stefanie Dimmeler; Peter Cserjesi; Thomas Eschenhagen; Paula A da Costa Martins; Leon J De Windt
Journal:  Nat Cell Biol       Date:  2013-10-27       Impact factor: 28.824

8.  MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice.

Authors:  Angelika Bonauer; Guillaume Carmona; Masayoshi Iwasaki; Marina Mione; Masamichi Koyanagi; Ariane Fischer; Jana Burchfield; Henrik Fox; Carmen Doebele; Kisho Ohtani; Emmanouil Chavakis; Michael Potente; Marc Tjwa; Carmen Urbich; Andreas M Zeiher; Stefanie Dimmeler
Journal:  Science       Date:  2009-05-21       Impact factor: 47.728

9.  Local inhibition of microRNA-24 improves reparative angiogenesis and left ventricle remodeling and function in mice with myocardial infarction.

Authors:  Marco Meloni; Micol Marchetti; Kathryn Garner; Ben Littlejohns; Graciela Sala-Newby; Natasa Xenophontos; Ilaria Floris; M-Saadeh Suleiman; Paolo Madeddu; Andrea Caporali; Costanza Emanueli
Journal:  Mol Ther       Date:  2013-06-18       Impact factor: 11.454

10.  Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis.

Authors:  Coen van Solingen; Leonard Seghers; Roel Bijkerk; Jacques M G J Duijs; Marko K Roeten; Annemarie M van Oeveren-Rietdijk; Hans J Baelde; Matthieu Monge; Joost B Vos; Hetty C de Boer; Paul H A Quax; Ton J Rabelink; Anton Jan van Zonneveld
Journal:  J Cell Mol Med       Date:  2009-08       Impact factor: 5.310
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  5 in total

1.  miRNA-30 family inhibition protects against cardiac ischemic injury by regulating cystathionine-γ-lyase expression.

Authors:  Yaqi Shen; Zhuqing Shen; Lei Miao; Xiaoming Xin; Shizhou Lin; Yichun Zhu; Wei Guo; Yi Zhun Zhu
Journal:  Antioxid Redox Signal       Date:  2014-10-27       Impact factor: 8.401

Review 2.  The Cardioprotective Effects of Hydrogen Sulfide in Heart Diseases: From Molecular Mechanisms to Therapeutic Potential.

Authors:  Yaqi Shen; Zhuqing Shen; Shanshan Luo; Wei Guo; Yi Zhun Zhu
Journal:  Oxid Med Cell Longev       Date:  2015-05-11       Impact factor: 6.543

3.  miRNome Profiling of Purified Endoderm and Mesoderm Differentiated from hESCs Reveals Functions of miR-483-3p and miR-1263 for Cell-Fate Decisions.

Authors:  Daichi Ishikawa; Ulf Diekmann; Jan Fiedler; Annette Just; Thomas Thum; Sigurd Lenzen; Ortwin Naujok
Journal:  Stem Cell Reports       Date:  2017-11-14       Impact factor: 7.765

4.  MicroRNA-93 inhibits ischemia-reperfusion induced cardiomyocyte apoptosis by targeting PTEN.

Authors:  Zun-Ping Ke; Peng Xu; Yan Shi; Ai-Mei Gao
Journal:  Oncotarget       Date:  2016-05-17

5.  miR-148a suppresses cell invasion and migration in gastric cancer by targeting DNA methyltransferase 1.

Authors:  Huaijie Shi; Xiaojing Chen; Hao Jiang; Xujie Wang; Hao Yu; Pijiang Sun; Xin Sui
Journal:  Oncol Lett       Date:  2018-01-31       Impact factor: 2.967
  5 in total

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