| Literature DB >> 24572992 |
Marina Lesina1, Sonja Maria Wörmann1, Patrick Neuhöfer1, Liang Song1, Hana Algül2.
Abstract
Interleukin-6 is an important pro-inflammatory cytokine strongly linked to the most burdened exocrine pancreatic diseases including acute pancreatitis, chronic pancreatitis and pancreatic cancer. However, its role in all these diseases is versatile and not completely defined. Several studies provided accumulating evidence that IL-6 is mainly involved in the JAK/STAT pathway activation promoting acute and chronic pancreatitis disease aggravation as well as pancreatic cancer initiation and progression. This review will focus on recent studies illustrating the role of IL-6 in acute and chronic pancreatitis and pancreatic oncogenesis. Further, a short overview of indicated disease pathologies will be given and the impact of IL-6 in JAK/STAT pathway, persistent STAT3 activation and cancer immunotherapy will be discussed.Entities:
Keywords: Acute pancreatitis; Chronic pancreatitis; IL-6 signaling; IL-6 trans-signaling; Pancreatic cancer; STAT3
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Year: 2014 PMID： 24572992 DOI： 10.1016/j.smim.2014.01.002
Source DB: PubMed Journal: Semin Immunol ISSN： 1044-5323 Impact factor: 11.130