AIM: To investigate changes of gut hormones in term and preterm infants in the first 2 months after birth, as the role and relationships of gut hormones in premature infants has not been well elucidated. METHODS: In 29 preterm and five term infants, fasting serum concentrations of leptin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), pancreatic polypeptide, insulin, amylin, and ghrelin were measured using a bead array system. RESULTS: Serum leptin concentration soon after birth showed a positive correlation with gestational week in all infants (r=0.623, p<0.01). Serum leptin level rapidly decreased in all infants. In preterm infants, serum GLP-1 levels at birth showed negative correlations with gestational week (r=-0.447, p=0.02). Serum GIP, GLP-1, and PYY levels increased after birth and were persistently high until 10 weeks of life. CONCLUSION: Serum concentrations of different gut hormones changed postnatally in their specific ways in preterm infants.
AIM: To investigate changes of gut hormones in term and preterm infants in the first 2 months after birth, as the role and relationships of gut hormones in premature infants has not been well elucidated. METHODS: In 29 preterm and five term infants, fasting serum concentrations of leptin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), pancreatic polypeptide, insulin, amylin, and ghrelin were measured using a bead array system. RESULTS: Serum leptin concentration soon after birth showed a positive correlation with gestational week in all infants (r=0.623, p<0.01). Serum leptin level rapidly decreased in all infants. In preterm infants, serum GLP-1 levels at birth showed negative correlations with gestational week (r=-0.447, p=0.02). Serum GIP, GLP-1, and PYY levels increased after birth and were persistently high until 10 weeks of life. CONCLUSION: Serum concentrations of different gut hormones changed postnatally in their specific ways in preterm infants.
Authors: Carl Frederik Hansen; Thomas Thymann; Anders Daniel Andersen; Jens Juul Holst; Bolette Hartmann; Linda Hilsted; Louise Langhorn; Jacob Jelsing; Per Torp Sangild Journal: Am J Physiol Gastrointest Liver Physiol Date: 2016-01-28 Impact factor: 4.052
Authors: María Dolores Ordóñez-Díaz; Mercedes Gil-Campos; Katherine Flores-Rojas; María Carmen Muñoz-Villanueva; Concepción María Aguilera-García; María Jose de la Torre-Aguilar; Juan Luis Pérez-Navero Journal: Nutrients Date: 2020-04-24 Impact factor: 5.717
Authors: Veronica Peotta; Kamal Rahmouni; Jeffrey L Segar; Donald A Morgan; Kate M Pitz; Olivia M Rice; Robert D Roghair Journal: Pediatr Res Date: 2016-04-06 Impact factor: 3.756