| Literature DB >> 24572114 |
Guillaume Monneret1, Astrid Villars-Méchin2, Julie Demaret1, Anne-Perrine Foray2, Fabienne Venet1.
Abstract
Sepsis-induced immunosuppression is a new paradigm in sepsis pathophysiology. This up-to-date review integrates recent facts in the field. It focuses on immune dysfunctions described so far in septic patients (especially regarding T lymphocytes), on the mechanisms sustaining this immune failure, on the monitoring of the pro-/anti-inflammatory balance rapidly changing over time and on new promising therapeutic avenues emerging from those recent findings. Of them, the case of interleukin-7 is more specifically envisaged.Entities:
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Year: 2014 PMID: 24572114 DOI: 10.1051/medsci/20143002013
Source DB: PubMed Journal: Med Sci (Paris) ISSN: 0767-0974 Impact factor: 0.818