| Literature DB >> 2456991 |
K M Reilly1, J Dawes, P L Yap, R S Barnetson, I R MacGregor.
Abstract
A new assay for highly-sulphated glycosaminoglycans (GAGs) has been applied to the study of allergen (Dermatophagoides pteronyssinus)-induced release of GAG from human basophils. Highly-sulphated GAG, which was not heparin, was found only in basophil-containing cellular fractions of whole blood. Its release, like that of histamine, was Ca++-dependent. However, allergen-induced release of GAG from the basophils of atopic individuals exhibited a different time-course and dose-response from that of histamine, and may occur at least in part by a different mechanism.Entities:
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Year: 1988 PMID： 2456991 DOI： 10.1159/000234583
Source DB: PubMed Journal: Int Arch Allergy Appl Immunol ISSN： 0020-5915