Literature DB >> 2456951

Palmitoyl-CoA inhibits the mitochondrial inner membrane anion-conducting channel.

S C Halle-Smith1, A G Murray, M J Selwyn.   

Abstract

Palmitoyl-CoA is shown here to inhibit the pH-dependent anion-conducting channel (IMAC) in the inner membrane of rat liver mitochondria, with half-maximal inhibition at 2.4 microM. It has little effect on the transport of ribose, thiocyanate and glutamate. Palmitic acid and palmitoyl-carnitine stimulate the entry of all the above metabolites. CoASH and carnitine have no effect on chloride uniport. Palmitoyl-CoA and the IMAC may have a role in controlling thermogenesis in liver mitochondria.

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Year:  1988        PMID： 2456951     DOI： 10.1016/0014-5793(88)80305-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

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