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Literature DB >> 24569364

NRF2 mitigates radiation-induced hematopoietic death.

Abstract

Fractionated, high-dose total body irradiation (TBI) is used therapeutically to myeloablate and immune suppress patients undergoing hematopoietic stem cell (HSC) transplantation. Acute exposure to ionizing radiation can have fatal effects on the hematopoietic and immune systems. Currently, therapies aimed at ameliorating ionizing radiation-associated toxicities are limited. In the February 2014 issue of the JCI, Kim and colleagues demonstrated that induction of nuclear factor erythroid 2-related factor 2 (NRF2) enhances HSC regeneration and increases survival following ionizing radiation exposure in mice. The results of this study suggest that NRF2 is a novel potential target for the development of therapeutics aimed at mitigating the toxicities of ionizing radiation exposure.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2014 PMID： 24569364 PMCID： PMC3938265 DOI： 10.1172/JCI74143

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

16 in total

1. Irradiation of the entire body and marrow transplantation: some observations and comments.

Authors: E D THOMAS; H L LOCHTE; J W FERREBEE
Journal: Blood Date: 1959-01 Impact factor: 22.113

2. NIAID/NIH radiation/nuclear medical countermeasures product research and development program.

Authors: Nathaniel Hafer; David Cassatt; Andrea Dicarlo; Narayani Ramakrishnan; Joseph Kaminski; Mai-Kim Norman; Bert Maidment; Richard Hatchett
Journal: Health Phys Date: 2010-06 Impact factor: 1.316

Review 3. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.

Authors: Thomas W Kensler; Nobunao Wakabayashi; Shyam Biswal
Journal: Annu Rev Pharmacol Toxicol Date: 2007 Impact factor: 13.820

4. Review of thirty years study of Hiroshima and Nagasaki atomic bomb survivors. II. Biological effects. A. Acute effects.

Authors: T Okita
Journal: J Radiat Res Date: 1975-09 Impact factor: 2.724

5. Methods for the study of histocompatibility genes.

Authors: G D SNELL
Journal: J Genet Date: 1948-10 Impact factor: 1.166

6. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. 1961.

Authors: J E Till; E A McCulloch
Journal: Radiat Res Date: 2012-08 Impact factor: 2.841

7. Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells.

Authors: Heather A Himburg; Garrett G Muramoto; Pamela Daher; Sarah K Meadows; J Lauren Russell; Phuong Doan; Jen-Tsan Chi; Alice B Salter; William E Lento; Tannishtha Reya; Nelson J Chao; John P Chute
Journal: Nat Med Date: 2010-03-21 Impact factor: 53.440

8. NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation.

Authors: Jung-Hyun Kim; Rajesh K Thimmulappa; Vineet Kumar; Wanchang Cui; Sarvesh Kumar; Ponvijay Kombairaju; Hao Zhang; Joseph Margolick; William Matsui; Thomas Macvittie; Sanjay V Malhotra; Shyam Biswal
Journal: J Clin Invest Date: 2014-01-27 Impact factor: 14.808

9. Filgrastim improves survival in lethally irradiated nonhuman primates.

Authors: Ann M Farese; Melanie V Cohen; Barry P Katz; Cassandra P Smith; Allison Gibbs; Daniel M Cohen; Thomas J MacVittie
Journal: Radiat Res Date: 2012-12-04 Impact factor: 2.841

10. Epidermal growth factor regulates hematopoietic regeneration after radiation injury.

Authors: Phuong L Doan; Heather A Himburg; Katherine Helms; J Lauren Russell; Emma Fixsen; Mamle Quarmyne; Jeffrey R Harris; Divino Deoliviera; Julie M Sullivan; Nelson J Chao; David G Kirsch; John P Chute
Journal: Nat Med Date: 2013-02-03 Impact factor: 53.440

7 in total

1. Time-Dependent Measurement of Nrf2-Regulated Antioxidant Response to Ionizing Radiation Toward Identifying Potential Protein Biomarkers for Acute Radiation Injury.

Authors: Kate Liu; Elizabeth Singer; Whitaker Cohn; Ewa D Micewicz; William H McBride; Julian P Whitelegge; Joseph A Loo
Journal: Proteomics Clin Appl Date: 2019-09-04 Impact factor: 3.494

NRF2 mitigates radiation-induced hematopoietic death.

1. Irradiation of the entire body and marrow transplantation: some observations and comments.

2. NIAID/NIH radiation/nuclear medical countermeasures product research and development program.

Review 3. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.

4. Review of thirty years study of Hiroshima and Nagasaki atomic bomb survivors. II. Biological effects. A. Acute effects.

5. Methods for the study of histocompatibility genes.

6. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. 1961.

7. Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells.

8. NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation.

9. Filgrastim improves survival in lethally irradiated nonhuman primates.

10. Epidermal growth factor regulates hematopoietic regeneration after radiation injury.

1. Time-Dependent Measurement of Nrf2-Regulated Antioxidant Response to Ionizing Radiation Toward Identifying Potential Protein Biomarkers for Acute Radiation Injury.

Review 2. Effects of ionizing radiation on the heart.

3. Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model.

Review 4. Radiotherapy-induced heart disease: a review of the literature.

Review 5. Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance.

6. Nrf2-Knockout Protects from Intestinal Injuries in C57BL/6J Mice Following Abdominal Irradiation with γ Rays.

Review 7. Reactive Oxygen Species and Nrf2: Functional and Transcriptional Regulators of Hematopoiesis.