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Literature DB >> 24569235

Stem cell fate regulation by dynein motor protein Lis1.

Abstract

Cell fate regulation is a central component of maintaining tissue homeostasis, yet the mechanisms instructing cell division diversity in tissue-specific stem cells have not been well understood. A new study uncovers a central role for microtubule motor-regulating protein Lis1 in hematopoietic stem cell fate determination and in leukemogenesis.

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Year: 2014 PMID： 24569235 DOI： 10.1038/ng.2902

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

15 in total

1. EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells.

Authors: Fiona Doetsch; Leopoldo Petreanu; Isabelle Caille; Jose Manuel Garcia-Verdugo; Arturo Alvarez-Buylla
Journal: Neuron Date: 2002-12-19 Impact factor: 17.173

2. An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity.

Authors: Kristin J Hope; Sonia Cellot; Stephen B Ting; Tara MacRae; Nadine Mayotte; Norman N Iscove; Guy Sauvageau
Journal: Cell Stem Cell Date: 2010-07-02 Impact factor: 24.633

3. Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization.

Authors: Jose A Cancelas; Andrew W Lee; Rethinasamy Prabhakar; Keith F Stringer; Yi Zheng; David A Williams
Journal: Nat Med Date: 2005-07-17 Impact factor: 53.440

4. Imaging hematopoietic precursor division in real time.

Authors: Mingfu Wu; Hyog Young Kwon; Frederique Rattis; Jordan Blum; Chen Zhao; Rina Ashkenazi; Trachette L Jackson; Nicholas Gaiano; Tim Oliver; Tannishtha Reya
Journal: Cell Stem Cell Date: 2007-11 Impact factor: 24.633

5. Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.

Authors: Michael G Kharas; Christopher J Lengner; Fatima Al-Shahrour; Lars Bullinger; Brian Ball; Samir Zaidi; Kelly Morgan; Winnie Tam; Mahnaz Paktinat; Rachel Okabe; Maricel Gozo; William Einhorn; Steven W Lane; Claudia Scholl; Stefan Fröhling; Mark Fleming; Benjamin L Ebert; D Gary Gilliland; Rudolf Jaenisch; George Q Daley
Journal: Nat Med Date: 2010-07-08 Impact factor: 53.440

6. Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast.

Authors: T Ohshiro; T Yagami; C Zhang; F Matsuzaki
Journal: Nature Date: 2000-11-30 Impact factor: 49.962

7. The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation.

Authors: Alexa S Green; Nicolas Chapuis; Thiago Trovati Maciel; Lise Willems; Mireille Lambert; Christophe Arnoult; Olivier Boyer; Valerie Bardet; Sophie Park; Marc Foretz; Benoit Viollet; Norbert Ifrah; François Dreyfus; Olivier Hermine; Ivan Cruz Moura; Catherine Lacombe; Patrick Mayeux; Didier Bouscary; Jerome Tamburini
Journal: Blood Date: 2010-07-28 Impact factor: 22.113

Stem cell fate regulation by dynein motor protein Lis1.

1. EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells.

2. An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity.

3. Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization.

4. Imaging hematopoietic precursor division in real time.

5. Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.

6. Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast.

7. The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation.

Review 8. Asymmetric cell division: recent developments and their implications for tumour biology.

9. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells.

10. A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.

Review 1. Prognostic significance of regulatory T lymphocytes in patients with hepatocellular carcinoma.

2. Preferential Association of Lissencephaly-1 Gene Expression with CD133+ Glioblastoma Cells.

3. Fighting Cancer Stem Cell Fate by Targeting LIS1 a WD40 Repeat Protein.