Literature DB >> 24569233

Intratumoral heterogeneity in kidney cancer.

Christopher J Ricketts1, W Marston Linehan1.   

Abstract

Clear cell renal cell carcinoma (CCRCC) is characterized by mutation of the VHL gene and loss of a segment of chromosome 3. A new study using multi-region exome sequencing has identified substantial intratumoral heterogeneity within large primary CCRCCs, which has profound implications for understanding tumor evolution and for developing effective therapies.

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Year:  2014        PMID： 24569233      PMCID： PMC4193312          DOI： 10.1038/ng.2904

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  13 in total

Review 1.  The genetic basis of kidney cancer: a metabolic disease.

Authors:  W Marston Linehan; Ramaprasad Srinivasan; Laura S Schmidt
Journal:  Nat Rev Urol       Date:  2010-05       Impact factor: 14.432

2.  Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network.

Authors:  A Ari Hakimi; Irina Ostrovnaya; Boris Reva; Nikolaus Schultz; Ying-Bei Chen; Mithat Gonen; Han Liu; Shugaku Takeda; Martin H Voss; Satish K Tickoo; Victor E Reuter; Paul Russo; Emily H Cheng; Chris Sander; Robert J Motzer; James J Hsieh
Journal:  Clin Cancer Res       Date:  2013-04-25       Impact factor: 12.531

3.  Integrated molecular analysis of clear-cell renal cell carcinoma.

Authors:  Yusuke Sato; Tetsuichi Yoshizato; Yuichi Shiraishi; Shigekatsu Maekawa; Yusuke Okuno; Takumi Kamura; Teppei Shimamura; Aiko Sato-Otsubo; Genta Nagae; Hiromichi Suzuki; Yasunobu Nagata; Kenichi Yoshida; Ayana Kon; Yutaka Suzuki; Kenichi Chiba; Hiroko Tanaka; Atsushi Niida; Akihiro Fujimoto; Tatsuhiko Tsunoda; Teppei Morikawa; Daichi Maeda; Haruki Kume; Sumio Sugano; Masashi Fukayama; Hiroyuki Aburatani; Masashi Sanada; Satoru Miyano; Yukio Homma; Seishi Ogawa
Journal:  Nat Genet       Date:  2013-06-24       Impact factor: 38.330

4.  Intratumor heterogeneity: seeing the wood for the trees.

Authors:  Timothy A Yap; Marco Gerlinger; P Andrew Futreal; Lajos Pusztai; Charles Swanton
Journal:  Sci Transl Med       Date:  2012-03-28       Impact factor: 17.956

5.  Tumour evolution inferred by single-cell sequencing.

Authors:  Nicholas Navin; Jude Kendall; Jennifer Troge; Peter Andrews; Linda Rodgers; Jeanne McIndoo; Kerry Cook; Asya Stepansky; Dan Levy; Diane Esposito; Lakshmi Muthuswamy; Alex Krasnitz; W Richard McCombie; James Hicks; Michael Wigler
Journal:  Nature       Date:  2011-03-13       Impact factor: 49.962

6.  A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy.

Authors:  Sandra Turcotte; Denise A Chan; Patrick D Sutphin; Michael P Hay; William A Denny; Amato J Giaccia
Journal:  Cancer Cell       Date:  2008-07-08       Impact factor: 31.743

7.  Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

Authors:  Marco Gerlinger; Andrew J Rowan; Stuart Horswell; James Larkin; David Endesfelder; Eva Gronroos; Pierre Martinez; Nicholas Matthews; Aengus Stewart; Charles Swanton; M Math; Patrick Tarpey; Ignacio Varela; Benjamin Phillimore; Sharmin Begum; Neil Q McDonald; Adam Butler; David Jones; Keiran Raine; Calli Latimer; Claudio R Santos; Mahrokh Nohadani; Aron C Eklund; Bradley Spencer-Dene; Graham Clark; Lisa Pickering; Gordon Stamp; Martin Gore; Zoltan Szallasi; Julian Downward; P Andrew Futreal
Journal:  N Engl J Med       Date:  2012-03-08       Impact factor: 91.245

8.  Comprehensive molecular characterization of clear cell renal cell carcinoma.

Authors: 
Journal:  Nature       Date:  2013-06-23       Impact factor: 49.962

9.  Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.

Authors:  Gillian L Dalgliesh; Kyle Furge; Chris Greenman; Lina Chen; Graham Bignell; Adam Butler; Helen Davies; Sarah Edkins; Claire Hardy; Calli Latimer; Jon Teague; Jenny Andrews; Syd Barthorpe; Dave Beare; Gemma Buck; Peter J Campbell; Simon Forbes; Mingming Jia; David Jones; Henry Knott; Chai Yin Kok; King Wai Lau; Catherine Leroy; Meng-Lay Lin; David J McBride; Mark Maddison; Simon Maguire; Kirsten McLay; Andrew Menzies; Tatiana Mironenko; Lee Mulderrig; Laura Mudie; Sarah O'Meara; Erin Pleasance; Arjunan Rajasingham; Rebecca Shepherd; Raffaella Smith; Lucy Stebbings; Philip Stephens; Gurpreet Tang; Patrick S Tarpey; Kelly Turrell; Karl J Dykema; Sok Kean Khoo; David Petillo; Bill Wondergem; John Anema; Richard J Kahnoski; Bin Tean Teh; Michael R Stratton; P Andrew Futreal
Journal:  Nature       Date:  2010-01-06       Impact factor: 49.962

10.  Genetic basis of kidney cancer: role of genomics for the development of disease-based therapeutics.

Authors:  W Marston Linehan
Journal:  Genome Res       Date:  2012-10-04       Impact factor: 9.043
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  20 in total

1.  An empirical likelihood ratio test robust to individual heterogeneity for differential expression analysis of RNA-seq.

Authors:  Maoqi Xu; Liang Chen
Journal:  Brief Bioinform       Date:  2018-01-01       Impact factor: 11.622

2.  New strategies in renal cell carcinoma: targeting the genetic and metabolic basis of disease.

Authors:  Ramaprasad Srinivasan; Christopher J Ricketts; Carole Sourbier; W Marston Linehan
Journal:  Clin Cancer Res       Date:  2015-01-01       Impact factor: 12.531

3.  Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma.

Authors:  Denise R Minton; Leiping Fu; Nigel P Mongan; Maria M Shevchuk; David M Nanus; Lorraine J Gudas
Journal:  Clin Cancer Res       Date:  2016-01-18       Impact factor: 12.531

4.  High fidelity of driver chromosomal alterations among primary and metastatic renal cell carcinomas: implications for tumor clonal evolution and treatment.

Authors:  Eril J Kouba; John N Eble; Novae Simper; David J Grignon; Mingsheng Wang; Shaobo Zhang; Lisha Wang; Guido Martignoni; Sean R Williamson; Matteo Brunelli; Claudio Luchini; Anna Calió; Liang Cheng
Journal:  Mod Pathol       Date:  2016-07-29       Impact factor: 7.842

5.  Ambient ionization mass spectrometric analysis of human surgical specimens to distinguish renal cell carcinoma from healthy renal tissue.

Authors:  Clint M Alfaro; Alan K Jarmusch; Valentina Pirro; Kevin S Kerian; Timothy A Masterson; Liang Cheng; R Graham Cooks
Journal:  Anal Bioanal Chem       Date:  2016-05-20       Impact factor: 4.142

6.  Computed Tomography Appearance of Renal Hybrid Oncocytic/Chromophobe Tumors.

Authors:  Akrita Bhatnagar; Steven P Rowe; Michael A Gorin; Martin G Pomper; Elliot K Fishman; Mohamad E Allaf
Journal:  J Comput Assist Tomogr       Date:  2016 Jul-Aug       Impact factor: 1.826

7.  Whole lesion quantitative CT evaluation of renal cell carcinoma: differentiation of clear cell from papillary renal cell carcinoma.

Authors:  Frank Chen; Hannu Huhdanpaa; Bhushan Desai; Darryl Hwang; Steven Cen; Andy Sherrod; Jean-Christophe Bernhard; Mihir Desai; Inderbir Gill; Vinay Duddalwar
Journal:  Springerplus       Date:  2015-02-10

Review 8.  Targeted therapies for renal cell carcinoma in Chinese patients: focus on everolimus.

Authors:  Xiaojie Tan; Yan Liu; Jianguo Hou; Guangwen Cao
Journal:  Onco Targets Ther       Date:  2015-01-29       Impact factor: 4.147

9.  Analyses of the transcriptome and metabolome demonstrate that HIF1α mediates altered tumor metabolism in clear cell renal cell carcinoma.

Authors:  Denise R Minton; Leiping Fu; Qiuying Chen; Brian D Robinson; Steven S Gross; David M Nanus; Lorraine J Gudas
Journal:  PLoS One       Date:  2015-04-01       Impact factor: 3.240

Review 10.  Tumour heterogeneity and the evolution of polyclonal drug resistance.

Authors:  Rebecca A Burrell; Charles Swanton
Journal:  Mol Oncol       Date:  2014-07-10       Impact factor: 6.603
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