Literature DB >> 24569091

Acetate/acetyl-CoA metabolism associated with cancer fatty acid synthesis: overview and application.

Yukie Yoshii1, Takako Furukawa2, Tsuneo Saga2, Yasuhisa Fujibayashi2.   

Abstract

Understanding cancer-specific metabolism is important for identifying novel targets for cancer diagnosis and therapy. Induced acetate/acetyl CoA metabolism is a notable feature that is related to fatty acid synthesis supporting tumor growth. In this review, we focused on the recent findings related to cancer acetate/acetyl CoA metabolism. We also introduce [1-¹¹C]acetate positron emission tomography (PET), which is a useful tool to visualize up-regulation of acetate/acetyl CoA metabolism in cancer, and discuss the utility of [1-¹¹C]acetate PET in cancer diagnosis and its application to personalized medicine.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Acetate; Acetyl CoA; Fatty acid; Metabolism; Positron emission tomography

Mesh：

Substances：

Year:  2014        PMID： 24569091     DOI： 10.1016/j.canlet.2014.02.019

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  31 in total

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