Literature DB >> 24568546

Dendritic cell lectin-targeting sentinel-like unimolecular glycoconjugates to release an anti-HIV drug.

Qiang Zhang1, Lu Su, Jennifer Collins, Guosong Chen, Russell Wallis, Daniel A Mitchell, David M Haddleton, C Remzi Becer.   

Abstract

A series of cyclodextrin-based glycoconjugates, including glycoclusters and star glycopolymers, were synthesized via combination of CuAAC Huisgen coupling and copper-mediated living radical polymerization. These glycoconjugates showed high affinity binding to the human transmembrane lectin DC-SIGN and act as inhibitors to prevent the binding of HIV envelope protein gp120 to DC-SIGN at nanomolar concentrations. The star block glycopolymers showed high loading capacity of hydrophobic anticancer and anti-HIV drugs, indicating promising applications in HIV-therapeutic and smart drug delivery.

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Year:  2014        PMID： 24568546     DOI： 10.1021/ja4131565

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  9 in total

1.  Multivalent Cluster Nanomolecules for Inhibiting Protein-Protein Interactions.

Authors:  Elaine A Qian; Yanxiao Han; Marco S Messina; Heather D Maynard; Petr Král; Alexander M Spokoyny
Journal:  Bioconjug Chem       Date:  2019-09-23       Impact factor: 4.774

Review 2.  Harnessing molecular recognition for localized drug delivery.

Authors:  Renjie Liu; Ran Zuo; Gregory A Hudalla
Journal:  Adv Drug Deliv Rev       Date:  2021-01-20       Impact factor: 15.470

3.  Enhanced Binding and Reduced Immunogenicity of Glycoconjugates Prepared via Solid-State Photoactivation of Aliphatic Diazirine Carbohydrates.

Authors:  Molly D Congdon; Jeffrey C Gildersleeve
Journal:  Bioconjug Chem       Date:  2020-12-16       Impact factor: 6.069

4.  Carbohydrate-Based Polymers for Immune Modulation.

Authors:  Kenneth Lin; Andrea M Kasko
Journal:  ACS Macro Lett       Date:  2014-06-17       Impact factor: 6.903

5.  Glycodendrimers and Modified ELISAs: Tools to Elucidate Multivalent Interactions of Galectins 1 and 3.

Authors:  Mark Wolfenden; Jonathan Cousin; Pratima Nangia-Makker; Avraham Raz; Mary Cloninger
Journal:  Molecules       Date:  2015-04-20       Impact factor: 4.411

Review 6.  The Role of Galectin-1 in Cancer Progression, and Synthetic Multivalent Systems for the Study of Galectin-1.

Authors:  Jonathan M Cousin; Mary J Cloninger
Journal:  Int J Mol Sci       Date:  2016-09-16       Impact factor: 5.923

7.  Manipulation of cytokine secretion in human dendritic cells using glycopolymers with picomolar affinity for DC-SIGN.

Authors:  Daniel A Mitchell; Qiang Zhang; Lenny Voorhaar; David M Haddleton; Shan Herath; Anne S Gleinich; Harpal S Randeva; Max Crispin; Hendrik Lehnert; Russell Wallis; Steven Patterson; C Remzi Becer
Journal:  Chem Sci       Date:  2017-08-16       Impact factor: 9.825

Review 8.  Molecular Recognition in C-Type Lectins: The Cases of DC-SIGN, Langerin, MGL, and L-Sectin.

Authors:  Pablo Valverde; J Daniel Martínez; F Javier Cañada; Ana Ardá; Jesús Jiménez-Barbero
Journal:  Chembiochem       Date:  2020-07-02       Impact factor: 3.461

9.  Synthetic Glycomacromolecules of Defined Valency, Absolute Configuration, and Topology Distinguish between Human Lectins.

Authors:  Manuel Hartweg; Yivan Jiang; Gokhan Yilmaz; Cassie M Jarvis; Hung V-T Nguyen; Gastón A Primo; Alessandra Monaco; Valentin P Beyer; Kathleen K Chen; Somesh Mohapatra; Simon Axelrod; Rafael Gómez-Bombarelli; Laura L Kiessling; C Remzi Becer; Jeremiah A Johnson
Journal:  JACS Au       Date:  2021-08-10
  9 in total

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