OBJECTIVES: The present study aimed to examine the cytogenetic and genetic mutation features of acute myeloid leukemia (AML) in elderly Chinese patients. METHODS: A retrospective analysis of cytogenetics and genetic mutations was performed in 113 cases (age range 50-82 years) with de novo AML. RESULTS: The most frequent cytogenetic abnormality was t (15;17) (q22;q21), detected in 10.0% (n = 9) of successfully analyzed cases, followed by t (8;21) (q22;q22) in 8.89% (n = 8), and complex karyotypes in 5.56% (n = 5). Those with complex karyotypes included 4 cases (4.44%) of monosomal karyotypes. The frequencies of NPM1, FLT3-ITD, c-kit, and CEBPA mutations were 27.4% (31/113), 14.5% (16/110), 5.88% (6/102), and 23.3% (7/30), respectively. The complete remission rates of patients in low, intermediate, and high risk groups were 37.5%, 48.6%, and 33.3%, respectively (χ2 = 0.704, P = 0.703) based on risk stratification. CONCLUSION: Cytogenetics and genetic mutations alone may not be sufficient to evaluate the prognoses of elderly AML patients. The search for a novel model that would enable a more comprehensive evaluation of this population is therefore imperative.
OBJECTIVES: The present study aimed to examine the cytogenetic and genetic mutation features of acute myeloid leukemia (AML) in elderly Chinese patients. METHODS: A retrospective analysis of cytogenetics and genetic mutations was performed in 113 cases (age range 50-82 years) with de novo AML. RESULTS: The most frequent cytogenetic abnormality was t (15;17) (q22;q21), detected in 10.0% (n = 9) of successfully analyzed cases, followed by t (8;21) (q22;q22) in 8.89% (n = 8), and complex karyotypes in 5.56% (n = 5). Those with complex karyotypes included 4 cases (4.44%) of monosomal karyotypes. The frequencies of NPM1, FLT3-ITD, c-kit, and CEBPA mutations were 27.4% (31/113), 14.5% (16/110), 5.88% (6/102), and 23.3% (7/30), respectively. The complete remission rates of patients in low, intermediate, and high risk groups were 37.5%, 48.6%, and 33.3%, respectively (χ2 = 0.704, P = 0.703) based on risk stratification. CONCLUSION: Cytogenetics and genetic mutations alone may not be sufficient to evaluate the prognoses of elderly AMLpatients. The search for a novel model that would enable a more comprehensive evaluation of this population is therefore imperative.
Authors: W S Hamadou; R E Abed; S Besbes; V Bourdon; A Fabre; Y B Youssef; M A Laatiri; F Eisinger; V Mari; P Gesta; H Dreyfus; V Bonadona; C Dugast; H Zattara; L Faivre; S Y Jemni; T Noguchi; A Khélif; H Sobol; Z Soua Journal: Clin Transl Oncol Date: 2015-08-19 Impact factor: 3.405
Authors: Muhammad Shariq Shaikh; Zeeshan Ansar Ahmed; Mohammad Usman Shaikh; Salman Naseem Adil; Mohammad Khurshid; Tariq Moatter; Anila Rashid; Farheen Karim; Ahmed Raheem; Natasha Ali Journal: Asian Pac J Cancer Prev Date: 2018-07-27
Authors: Gledson L Picharski; Diancarlos P Andrade; Ana Luiza M R Fabro; Luana Lenzi; Fernanda S Tonin; Raul C Ribeiro; Bonald C Figueiredo Journal: Cancers (Basel) Date: 2019-09-05 Impact factor: 6.639