Karim P Manji1, Christine M McDonald2, Roland Kupka3, Ronald J Bosch4, Rodrick Kisenge5, Said Aboud6, David C Bellinger7, Wafaie W Fawzi8, Christopher P Duggan9. 1. Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Upanga, Dar es Salaam, Tanzania*Karim P. Manji and Christine M. McDonald are joint first authors. 2. Division of Gastroenterology, Hepatology and Nutrition, Boston Hospital, Boston, MA 02115, USA*Karim P. Manji and Christine M. McDonald are joint first authors. 3. UNICEF West and Central Africa Regional Office, Immeuble Maimouna III, Yoff, Dakar, SenegalDepartment of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. 4. Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA. 5. Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Upanga, Dar es Salaam, Tanzania. 6. Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Upanga, Dar es Salaam, Tanzania. 7. Department of Neurology, Boston Children's Hospital, Boston, MA 02115, USADepartment of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA. 8. Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USADepartment of Global Health and Population, Harvard School of Public Health, Boston, MA 02115, USADepartment of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. 9. Division of Gastroenterology, Hepatology and Nutrition, Boston Hospital, Boston, MA 02115, USADepartment of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA christopher.duggan@childrens.harvard.edu.
Abstract
BACKGROUND: Micronutrient deficiencies and in utero exposure to HIV may impair infant neurodevelopment. OBJECTIVE: To evaluate the effect of daily multivitamin supplementation on the cognitive, language and motor development of HIV-exposed Tanzanian infants. METHODS: A total of 2387 infants were randomized to receive daily oral supplementation of multivitamins (B-complex, C and E) or placebo from age 6 weeks for 24 months. The cognitive, language and motor scales of the Bayley Scales of Infant and Toddler Development, third edition, were administered to a subset of 206 infants at age 15 months. RESULTS:Multivitamin supplementation did not improve measures of cognitive development, expressive or receptive language or gross motor capabilities. There was a trend toward improved fine motor skills among infants randomized to the multivitamin group (difference in mean score = 0.38; 95% CI = -0.01, 0.78, p = 0.06). CONCLUSION: Daily provision of multivitamins to HIV-exposed infants does not substantially improve developmental outcomes at age 15 months.
RCT Entities:
BACKGROUND: Micronutrient deficiencies and in utero exposure to HIV may impair infant neurodevelopment. OBJECTIVE: To evaluate the effect of daily multivitamin supplementation on the cognitive, language and motor development of HIV-exposed Tanzanian infants. METHODS: A total of 2387 infants were randomized to receive daily oral supplementation of multivitamins (B-complex, C and E) or placebo from age 6 weeks for 24 months. The cognitive, language and motor scales of the Bayley Scales of Infant and Toddler Development, third edition, were administered to a subset of 206 infants at age 15 months. RESULTS: Multivitamin supplementation did not improve measures of cognitive development, expressive or receptive language or gross motor capabilities. There was a trend toward improved fine motor skills among infants randomized to the multivitamin group (difference in mean score = 0.38; 95% CI = -0.01, 0.78, p = 0.06). CONCLUSION: Daily provision of multivitamins to HIV-exposed infants does not substantially improve developmental outcomes at age 15 months.
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