BACKGROUND AND OBJECTIVE: Behçet's disease (BD) is a chronic inflammatory vasculitis presenting with flares and silent periods usually between 15 and 40 years of age. The aim of this study was to evaluate the possible association between Rho-kinase 1 (ROCK1) gene polymorphisms and patients with BD in a Turkish population. METHODS: A total of 192 BD patients and 255 healthy controls of similar age and sex were enrolled in this study. Polymorphisms were analyzed in genomic DNA using a BioMark HD dynamic array system. RESULTS: In the presence of CC genotype for rs73963110, CT genotype for rs111874856 (Val355Ile), and TC genotype for rs112130712 (Lys1054Arg) polymorphisms, the risk of BD increased 12.13-, 15.05-, and 16.28-fold, respectively (p < 0.0001). There was a lower frequency of the GA genotype of the rs112108028 (Pro1164Leu) polymorphisms in BD (10.3 %) compared with controls (39.7 %; p < 0.0001). Marked associations between these polymorphisms and the manifestations of BD were recorded. CONCLUSION: This is the first study to show that ROCK1 gene polymorphisms may have a significant impact on susceptibility to BD.
BACKGROUND AND OBJECTIVE: Behçet's disease (BD) is a chronic inflammatory vasculitis presenting with flares and silent periods usually between 15 and 40 years of age. The aim of this study was to evaluate the possible association between Rho-kinase 1 (ROCK1) gene polymorphisms and patients with BD in a Turkish population. METHODS: A total of 192 BD patients and 255 healthy controls of similar age and sex were enrolled in this study. Polymorphisms were analyzed in genomic DNA using a BioMark HD dynamic array system. RESULTS: In the presence of CC genotype for rs73963110, CT genotype for rs111874856 (Val355Ile), and TC genotype for rs112130712 (Lys1054Arg) polymorphisms, the risk of BD increased 12.13-, 15.05-, and 16.28-fold, respectively (p < 0.0001). There was a lower frequency of the GA genotype of the rs112108028 (Pro1164Leu) polymorphisms in BD (10.3 %) compared with controls (39.7 %; p < 0.0001). Marked associations between these polymorphisms and the manifestations of BD were recorded. CONCLUSION: This is the first study to show that ROCK1 gene polymorphisms may have a significant impact on susceptibility to BD.
Authors: N Mizuki; M Ota; K Yabuki; Y Katsuyama; H Ando; G D Palimeris; E Kaklamani; M Accorinti; P Pivetti-Pezzi; S Ohno; H Inoko Journal: Invest Ophthalmol Vis Sci Date: 2000-11 Impact factor: 4.799
Authors: S Bekpinar; N Kiliç; Y Unlüçerçi; A Akdag-Köse; G Azizlerli; Z Ozbek-Kir Journal: J Eur Acad Dermatol Venereol Date: 2005-03 Impact factor: 6.166
Authors: Yasemin D Akcay; Ferhan G Sagin; Kenan Aksu; Gokhan Keser; Emma Taylor; Iona Knight; Paul G Winyard; Eser Y Sozmen Journal: J Inflamm (Lond) Date: 2012-04-03 Impact factor: 4.981