| Literature DB >> 24565076 |
Hua Xu1, Xiao-Li Li2, Long-Tao Yue3, Heng Li2, Min Zhang2, Shan Wang2, Cong-Cong Wang2, Rui-Sheng Duan4.
Abstract
Statins have pleiotropic effects which include anti-inflammatory and immunomodulatory effects. In the present study, dendritic cells treated with atorvastatin (statin-DCs) could be induced into tolerogenic DCs. Administration of these tolerogenic DCs ameliorated clinical symptoms in experimental autoimmune neuritis (EAN), which was associated with reduced number of inflammatory cells in sciatic nerves, inhibited CD4(+) T cells proliferation, down-regulated expression of co-stimulatory molecules (CD80 and CD86) and MHC class II, decreased levels of IFN-γ, TNF-α and IL-17A, increased number of NKR-P1(+) cells (including NK and NKT cells), up-regulated number of Treg cells in lymph node MNC as well as increased Foxp3 expression in the thymus. These data indicated that statin-DCs could develop as a new therapeutic strategy to GBS in the future.Entities:
Keywords: Cytokines; Dendritic cells; Experimental autoimmune neuritis; NKR-P1(+) cells; Statins
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Year: 2014 PMID： 24565076 DOI： 10.1016/j.jneuroim.2014.02.002
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478