| Literature DB >> 24565075 |
Yi Cheng1, Hideyuki Takeuchi2, Yoshifumi Sonobe1, Shijie Jin1, Yue Wang1, Hiroshi Horiuchi1, Bijay Parajuli1, Jun Kawanokuchi1, Tetsuya Mizuno1, Akio Suzumura1.
Abstract
Sirtuin 1 (SIRT1) exerts a neuroprotective effect on various neurologic diseases. Here we investigated the protective functions of SIRT1 in astrocytes, which are the most abundant cells in the central nervous system. Upregulation of SIRT1 suppressed the expression levels of pro-inflammatory cytokines and increased the expression levels of superoxide dismutase 2 and catalase. Inversely, inhibition of SIRT1 significantly increased the acetylation of forkhead box protein O4, decreased the expression levels of superoxide dismutase 2 and catalase, and increased the production of reactive oxygen species. Our data suggest that astrocytic SIRT1 may elicit neuroprotective effects through its anti-oxidative and anti-inflammatory functions.Entities:
Keywords: Astrocyte; Catalase; Forkhead box protein O4; Reactive oxygen species; Sirtuin 1; Superoxide dismutase 2
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Year: 2014 PMID： 24565075 DOI： 10.1016/j.jneuroim.2014.02.001
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478