OBJECTIVE: To evaluate the hearing of adolescents with diabetes mellitus type 1(DM1) by otoacoustic emissions (OAEs), and by comparing different tests with pure-tone audiometry to identify potential early cochlear impairments. DESIGN: Pure-tone audiometry, transient evoked otoacoustic emissions (TEOAEs), and distortion product otoacoustic emissions (DPOAEs) were performed in a group of adolescents with and without DM1. Clinical characteristics, disease duration, and glycated haemoglobin levels were studied. STUDY SAMPLE: Participants were 40 adolescents with DM1 and 40 healthy subjects. RESULTS: Sensorineural hearing loss, affecting frequencies of 6000 and 8000 Hz, was found only in DM1 subjects when compared to the controls (7.7% vs. 0%, p < 0.05). A higher prevalence of cochlear damage was detected by DPOAE responses, 32% belonging from the diabetic group, vs. 3.7% in the control group. Absent TEOAE responses were observed in only three individuals, all from the diabetic group (5.1% of the tests performed in the diabetic group). Additionally, hearing thresholds were better in diabetic subjects with good control when compared to ones with regular or poor control (p = 0.00). Hearing thresholds were higher in poorly controlled diabetics when compared to subjects with good (p = 0.000) or regular control (p = 0.006). CONCLUSION: Early evidence of cochlear damage was detected in adolescents with DM1 leading to hearing loss at high frequencies. Abnormal DPOAEs responses were found more frequently than the alterations in TEOAEs and pure-tone audiometry, suggesting that DPOAEs evaluation is the most sensitive and it could be used for monitoring the progression of cochlear damage during the early stages of hearing impairment.
OBJECTIVE: To evaluate the hearing of adolescents with diabetes mellitus type 1(DM1) by otoacoustic emissions (OAEs), and by comparing different tests with pure-tone audiometry to identify potential early cochlear impairments. DESIGN: Pure-tone audiometry, transient evoked otoacoustic emissions (TEOAEs), and distortion product otoacoustic emissions (DPOAEs) were performed in a group of adolescents with and without DM1. Clinical characteristics, disease duration, and glycated haemoglobin levels were studied. STUDY SAMPLE: Participants were 40 adolescents with DM1 and 40 healthy subjects. RESULTS:Sensorineural hearing loss, affecting frequencies of 6000 and 8000 Hz, was found only in DM1 subjects when compared to the controls (7.7% vs. 0%, p < 0.05). A higher prevalence of cochlear damage was detected by DPOAE responses, 32% belonging from the diabetic group, vs. 3.7% in the control group. Absent TEOAE responses were observed in only three individuals, all from the diabetic group (5.1% of the tests performed in the diabetic group). Additionally, hearing thresholds were better in diabetic subjects with good control when compared to ones with regular or poor control (p = 0.00). Hearing thresholds were higher in poorly controlled diabetics when compared to subjects with good (p = 0.000) or regular control (p = 0.006). CONCLUSION: Early evidence of cochlear damage was detected in adolescents with DM1 leading to hearing loss at high frequencies. Abnormal DPOAEs responses were found more frequently than the alterations in TEOAEs and pure-tone audiometry, suggesting that DPOAEs evaluation is the most sensitive and it could be used for monitoring the progression of cochlear damage during the early stages of hearing impairment.
Entities:
Keywords:
Diabetes mellitus; cochlea; hearing loss; sensorineural; type 1
Authors: Alessandra G Samelli; Itamar S Santos; Renata R Moreira; Camila M Rabelo; Laurie P Rolim; Isabela J Bensenõr; Paulo A Lotufo Journal: Clinics (Sao Paulo) Date: 2017-01-01 Impact factor: 2.365
Authors: João Soares Felício; Lilian de Souza d'Albuquerque Silva; Carlliane Lima E Lins Pinto Martins; João Felício Abrahão Neto; Manuela Nascimento de Lemos; Fabrício de Souza Resende; Wanderson Maia da Silva; Angélica Leite de Alcântara; Maria Clara Neres Iunes de Oliveira; Norberto Jorge Kzan de Souza Neto; Isabela Imbelloni Farias de Franco; Nathalie Abdallah Zahalan; Luísa Correa Janaú; Ana Carolina Contente Braga de Souza; Flavia Marques Santos; Natércia Neves Marques de Queiroz; Neyla Arroyo Lara Mourão; Márcia Costa Dos Santos; Karem Miléo Felício; Franciane Trindade Cunha de Melo Journal: Diabetol Metab Syndr Date: 2018-11-09 Impact factor: 3.320