| Literature DB >> 24562056 |
Zhiqiang Jia1, Min Liu1, Zhe Qu1, Yuanyuan Zhang1, Shutong Yin1, Anshan Shan2.
Abstract
An experiment was conducted to determine the toxic effects of zearalenone (ZEN) on oxidative stress, inflammatory cytokines, biochemical and pathological changes in the kidney of pregnant rats, and to explore the possible mechanism in ZEN induced kidney damage. The rats were fed a normal diet treated with 0.3, 48.5, 97.6 or 146 mg/kg ZEN in feed on gestation days (GDs) 0 through 7, and then all the rats were fed with a normal diet on GDs 8 through 20. The results showed that ZEN induced kidney dysfunction, oxidative damage, pathological changes and increased mRNA and protein expression of TLR4 and inflammatory cytokines in kidney in dose-dependent manner. The results indicated that ZEN caused kidney damage of pregnant rats and TLR4-mediated inflammatory reactions signal pathway was one of the mechanisms of ZEN mediated toxicity in kidney.Entities:
Keywords: Biochemical and pathological changes; Inflammatory cytokines; Kidney; Oxidative stress; Pregnant rats; Zearalenone
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Year: 2014 PMID： 24562056 DOI： 10.1016/j.etap.2014.01.010
Source DB: PubMed Journal: Environ Toxicol Pharmacol ISSN： 1382-6689 Impact factor: 4.860