| Literature DB >> 24560657 |
Peter Fickert1, Marion J Pollheimer2, Ulrich Beuers3, Carolin Lackner4, Gideon Hirschfield5, Chantal Housset6, Verena Keitel7, Christoph Schramm8, Hanns-Ulrich Marschall9, Tom H Karlsen10, Espen Melum11, Arthur Kaser12, Bertus Eksteen13, Mario Strazzabosco14, Michael Manns15, Michael Trauner16.
Abstract
Primary sclerosing cholangitis (PSC) is a chronic cholangiopathy characterized by biliary fibrosis, development of cholestasis and end stage liver disease, high risk of malignancy, and frequent need for liver transplantation. The poor understanding of its pathogenesis is also reflected in the lack of effective medical treatment. Well-characterized animal models are utterly needed to develop novel pathogenetic concepts and study new treatment strategies. Currently there is no consensus on how to evaluate and characterize potential PSC models, which makes direct comparison of experimental results and effective exchange of study material between research groups difficult. The International Primary Sclerosing Cholangitis Study Group (IPSCSG) has therefore summarized these key issues in a position paper proposing standard requirements for the study of animal models of PSC.Entities:
Keywords: Animal model; Bile acids; Biliary fibrosis; Cholangiopathies; Cholestatic liver disease; Primary sclerosing cholangitis
Mesh：
Year: 2014 PMID： 24560657 PMCID： PMC4517670 DOI： 10.1016/j.jhep.2014.02.006
Source DB: PubMed Journal: J Hepatol ISSN： 0168-8278 Impact factor: 25.083