Literature DB >> 2456059

Inhibition of rapid Ca-release from isolated skeletal and cardiac sarcoplasmic reticulum (SR) membranes.

M Chiesi1, R Schwaller, G Calviello.   

Abstract

Rapid Ca-release from the cisternal compartments isolated from skeletal and cardiac muscle SR was characterized by the use of inhibitors. Ruthenium red (RR) completely blocked (IC50 = 90 nM) the Ca-channels of skeletal SR. Its effect on the rapid Ca-release from cardiac SR was marginal but became optimal (IC50 = 200 nM) in the presence of FLA 365 ([2,6-dichloro-4-dimethyl-aminophenyl] isopropylamine) which by itself had no measurable effect. The antibiotic neomycin mimicked the properties of RR. The strong synergistic effect of RR or neomycin and FLA 365 indicates that either cardiac cisternae contain two distinct isoforms of Ca-release channel, or that different drugs are needed to effectively block the same channel.

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Year:  1988        PMID： 2456059     DOI： 10.1016/0006-291x(88)90641-9

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms.

Authors:  Dongren Yang; Izabela Kania-Korwel; Atefeh Ghogha; Hao Chen; Marianna Stamou; Diptiman D Bose; Isaac N Pessah; Hans-Joachim Lehmler; Pamela J Lein
Journal:  Toxicol Sci       Date:  2014-01-02       Impact factor: 4.849

2.  From the Cover: BDE-47 and BDE-49 Inhibit Axonal Growth in Primary Rat Hippocampal Neuron-Glia Co-Cultures via Ryanodine Receptor-Dependent Mechanisms.

Authors:  Hao Chen; Karin M Streifel; Vikrant Singh; Dongren Yang; Linley Mangini; Heike Wulff; Pamela J Lein
Journal:  Toxicol Sci       Date:  2017-04-01       Impact factor: 4.849

3.  Mitochondrial calcium transients in adult rabbit cardiac myocytes: inhibition by ruthenium red and artifacts caused by lysosomal loading of Ca(2+)-indicating fluorophores.

Authors:  D R Trollinger; W E Cascio; J J Lemasters
Journal:  Biophys J       Date:  2000-07       Impact factor: 4.033

4.  The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation.

Authors:  Adam Lesiak; Mingyan Zhu; Hao Chen; Suzanne M Appleyard; Soren Impey; Pamela J Lein; Gary A Wayman
Journal:  J Neurosci       Date:  2014-01-15       Impact factor: 6.167

Review 5.  Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity.

Authors:  Isaac N Pessah; Gennady Cherednichenko; Pamela J Lein
Journal:  Pharmacol Ther       Date:  2009-11-25       Impact factor: 12.310

6.  PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms.

Authors:  Gary A Wayman; Dongren Yang; Diptiman D Bose; Adam Lesiak; Veronica Ledoux; Donald Bruun; Isaac N Pessah; Pamela J Lein
Journal:  Environ Health Perspect       Date:  2012-04-25       Impact factor: 9.031

Review 7.  Evidence Implicating Non-Dioxin-Like Congeners as the Key Mediators of Polychlorinated Biphenyl (PCB) Developmental Neurotoxicity.

Authors:  Carolyn Klocke; Pamela J Lein
Journal:  Int J Mol Sci       Date:  2020-02-04       Impact factor: 5.923
  7 in total

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