Literature DB >> 24560270

Too sweet for autophagy: hexokinase inhibition of mTORC1 activates autophagy.

Mondira Kundu1.   

Abstract

In this issue, Roberts et al. (2014) describe how hexokinase and mTORC1 cooperate to sense disequilibrium between glucose uptake and utilization and direct the balance of anabolism and catabolism to ensure the appropriate use of cellular resources.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 24560270      PMCID： PMC4106709          DOI： 10.1016/j.molcel.2014.02.009

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  9 in total

1.  mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

Authors:  Masahiro Morita; Simon-Pierre Gravel; Valérie Chénard; Kristina Sikström; Liang Zheng; Tommy Alain; Valentina Gandin; Daina Avizonis; Meztli Arguello; Chadi Zakaria; Shannon McLaughlan; Yann Nouet; Arnim Pause; Michael Pollak; Eyal Gottlieb; Ola Larsson; Julie St-Pierre; Ivan Topisirovic; Nahum Sonenberg
Journal:  Cell Metab       Date:  2013-11-05       Impact factor: 27.287

Review 2.  AMPK and mTOR in cellular energy homeostasis and drug targets.

Authors:  Ken Inoki; Joungmok Kim; Kun-Liang Guan
Journal:  Annu Rev Pharmacol Toxicol       Date:  2011-10-17       Impact factor: 13.820

3.  Glucose-6-phosphate isomerase deficiency results in mTOR activation, failed translocation of lipin 1α to the nucleus and hypersensitivity to glucose: Implications for the inherited glycolytic disease.

Authors:  Jorge F Haller; Sarah A Krawczyk; Lubov Gostilovitch; Barbara E Corkey; Raphael A Zoeller
Journal:  Biochim Biophys Acta       Date:  2011-07-21

4.  AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.

Authors:  Joungmok Kim; Mondira Kundu; Benoit Viollet; Kun-Liang Guan
Journal:  Nat Cell Biol       Date:  2011-01-23       Impact factor: 28.824

5.  Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.

Authors:  Liron Bar-Peled; Lawrence D Schweitzer; Roberto Zoncu; David M Sabatini
Journal:  Cell       Date:  2012-09-14       Impact factor: 41.582

6.  Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.

Authors:  Alejo Efeyan; Roberto Zoncu; Steven Chang; Iwona Gumper; Harriet Snitkin; Rachel L Wolfson; Oktay Kirak; David D Sabatini; David M Sabatini
Journal:  Nature       Date:  2012-12-23       Impact factor: 49.962

Review 7.  Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

Authors:  Christian C Dibble; Brendan D Manning
Journal:  Nat Cell Biol       Date:  2013-06       Impact factor: 28.824

8.  Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart.

Authors:  Shiraj Sen; Bijoy K Kundu; Henry Cheng-Ju Wu; S Shahrukh Hashmi; Patrick Guthrie; Landon W Locke; R Jack Roy; G Paul Matherne; Stuart S Berr; Matthew Terwelp; Brian Scott; Sylvia Carranza; O Howard Frazier; David K Glover; Wolfgang H Dillmann; Michael J Gambello; Mark L Entman; Heinrich Taegtmeyer
Journal:  J Am Heart Assoc       Date:  2013-05-17       Impact factor: 5.501

9.  Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart.

Authors:  Nirmala Hariharan; Yoshiyuki Ikeda; Chull Hong; Ralph R Alcendor; Soichiro Usui; Shumin Gao; Yasuhiro Maejima; Junichi Sadoshima
Journal:  PLoS One       Date:  2013-01-07       Impact factor: 3.240
  9 in total
  4 in total

1.  Elevated Hexokinase II Expression Confers Acquired Resistance to 4-Hydroxytamoxifen in Breast Cancer Cells.

Authors:  Xiaochuan Liu; Weili Miao; Ming Huang; Lin Li; Xiaoxia Dai; Yinsheng Wang
Journal:  Mol Cell Proteomics       Date:  2019-09-13       Impact factor: 5.911

Review 2.  Triterpenes in cancer: significance and their influence.

Authors:  Balraj Singh Gill; Sanjeev Kumar
Journal:  Mol Biol Rep       Date:  2016-06-25       Impact factor: 2.316

3.  Carbohydrate-Induced Insulin Signaling Activates Focal Adhesion Kinase: A Nutrient and Mechanotransduction Crossroads.

Authors:  Dylan T Wilburn; Steven B Machek; Thomas D Cardaci; Darryn S Willoughby
Journal:  Nutrients       Date:  2020-10-15       Impact factor: 5.717

4.  Hexokinase 2 Inhibition and Biological Effects of BNBZ and Its Derivatives: The Influence of the Number and Arrangement of Hydroxyl Groups.

Authors:  Karolina Juszczak; Anna Kubicka; Radosław Kitel; Grzegorz Dzido; Magdalena Łabieniec-Watała; Serafin Zawadzki; Agnieszka Marczak; Krzysztof Walczak; Karolina Matczak; Mateusz D Tomczyk
Journal:  Int J Mol Sci       Date:  2022-02-27       Impact factor: 5.923
  4 in total

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