| Literature DB >> 24560191 |
Abstract
In this issue of Immunity, Funabiki et al. (2014) have identified in mice a mutation of the IFIH1 gene, encoding the viral receptor MDA5 that causes constitutive IFN production and fatal autoimmune disease. The authors show that the autoimmune disease-associated variant of human MDA5 is permanently switched on.Entities:
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Year: 2014 PMID： 24560191 DOI： 10.1016/j.immuni.2014.01.009
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745