Literature DB >> 2455989

Evidence for the lack of involvement of free radicals in adriamycin-induced histamine release from rat peritoneal cells.

L Candussio1, F Bartoli Klugmann, G Decorti, L Baldini.   

Abstract

The antineoplastic drug adriamycin, at a concentration of 100 micrograms/ml, caused a significant histamine release from rat peritoneal mast cells. This exocytotic process was unaffected by pretreatment with various concentrations of catalase, superoxide-dismutase, D-mannitol, alpha-tocopherol and reduced glutathione. Only very high concentrations of n-acetylcysteine significantly limited this release; this substance was also active in limiting histamine secretion induced by a classic mast cell secretagogue, compound 48/80.

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Year:  1988        PMID： 2455989     DOI： 10.1007/bf02142540

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  10 in total

1.  A method for the fluorometric assay of histamine in tissues.

Authors:  P A SHORE; A BURKHALTER; V H COHN
Journal:  J Pharmacol Exp Ther       Date:  1959-11       Impact factor: 4.030

2.  Characterization of histamine secretion induced by anthracyclines in rat peritoneal mast cells.

Authors:  G Decorti; F Bartoli Klugmann; L Candussio; L Baldini
Journal:  Biochem Pharmacol       Date:  1986-06-15       Impact factor: 5.858

3.  Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response.

Authors:  C E Myers; W P McGuire; R H Liss; I Ifrim; K Grotzinger; R C Young
Journal:  Science       Date:  1977-07-08       Impact factor: 47.728

4.  Histamine release by free radicals: paracetamol-induced histamine release from rat peritoneal mast cells after in vitro activation by monooxygenase.

Authors:  E Masini; M Lodovici; R Fantozzi; S Brunelleschi; A Conti; P F Mannaioni
Journal:  Agents Actions       Date:  1986-04

5.  Xanthine oxidase-induced histamine release from isolated rat peritoneal mast cells: involvement of hydrogen peroxide.

Authors:  H Ohmori; K Komoriya; A Azuma; S Kurozumi; Y Hashimoto
Journal:  Biochem Pharmacol       Date:  1979       Impact factor: 5.858

6.  Mediation of subacute anthracycline cardiotoxicity in rabbits by cardiac histamine release.

Authors:  M R Bristow; N E Kantrowitz; W D Harrison; W A Minobe; W S Sageman; M E Billingham
Journal:  J Cardiovasc Pharmacol       Date:  1983 Nov-Dec       Impact factor: 3.105

Review 7.  Doxorubicin cardiotoxicity.

Authors:  D V Unverferth; R D Magorien; C V Leier; S P Balcerzak
Journal:  Cancer Treat Rev       Date:  1982-06       Impact factor: 12.111

8.  Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine.

Authors:  J H Doroshow; G Y Locker; I Ifrim; C E Myers
Journal:  J Clin Invest       Date:  1981-10       Impact factor: 14.808

9.  Acute and chronic cardiovascular effects of doxorubicin in the dog: the cardiovascular pharmacology of drug-induced histamine release.

Authors:  M R Bristow; W S Sageman; R H Scott; M E Billingham; R E Bowden; R S Kernoff; G H Snidow; J R Daniels
Journal:  J Cardiovasc Pharmacol       Date:  1980 Sep-Oct       Impact factor: 3.105

10.  Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo.

Authors:  F B Klugmann; G Decorti; L Candussio; V Grill; F Mallardi; L Baldini
Journal:  Br J Cancer       Date:  1986-11       Impact factor: 7.640
  10 in total

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