Anne C Torbergsen1, Leiv O Watne2, Torgeir B Wyller3, Frede Frihagen4, Knut Strømsøe5, Thomas Bøhmer6, Morten Mowe7. 1. Oslo University Hospital, Oslo, Norway; Department of General Internal Medicine, Oslo, Norway. Electronic address: a.c.torbergsen@medisin.uio.no. 2. Oslo University Hospital, Oslo, Norway; Department of Geriatric Medicine, Oslo, Norway. 3. Oslo University Hospital, Oslo, Norway; Department of Geriatric Medicine, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Norway. 4. Oslo University Hospital, Oslo, Norway; Department of Orthopedic Medicine, Oslo, Norway. 5. Oslo University Hospital, Oslo, Norway; Department of Orthopedic Medicine, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Norway. 6. Oslo University Hospital, Oslo, Norway; Department of Biochemistry, Nutrition Laboratory, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Norway. 7. Oslo University Hospital, Oslo, Norway; Department of General Internal Medicine, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Norway.
Abstract
BACKGROUND & AIMS: The incidence of hip fractures in Oslo is among the highest in the world. Vitamin D, as well as vitamin K, may play an important role in bone metabolism. We examined if vitamin K1 and 25(OH)D were associated with an increased risk of hip fracture, and whether the possible synergistic effect of these two micronutrients is mediated through bone turnover markers. METHODS: Blood was drawn for vitamin K1, 25(OH)D, and the bone turnover marker osteocalcin upon admission for hip fracture and in healthy controls. RESULTS: Vitamin K1 and 25(OH)D were independently associated with a risk of hip fracture. The adjusted odds ratio (95% CI) per ng/ml increase in vitamin K1 was 0.07 (0.02-0.32), and that per nmol/L increase in 25(OH)D was 0.96 (0.95-0.98). There was a significant interaction between 25(OH)D and vitamin K1 (p < 0.001), and a significant correlation between total osteocalcin and vitamin K1 and 25(OH)D (rho = 0.18, p = 0.01; rho = 0.20, p = 0.01, respectively). CONCLUSIONS: Vitamin K1 and 25(OH)D are lower in hip fracture patients compared with controls. Vitamin K1 and 25(OH)D are independently and synergistically associated with the risk of hip fracture when adjusting for confounders. Intervention studies should include both vitamins. Crown
BACKGROUND & AIMS: The incidence of hip fractures in Oslo is among the highest in the world. Vitamin D, as well as vitamin K, may play an important role in bone metabolism. We examined if vitamin K1 and 25(OH)D were associated with an increased risk of hip fracture, and whether the possible synergistic effect of these two micronutrients is mediated through bone turnover markers. METHODS: Blood was drawn for vitamin K1, 25(OH)D, and the bone turnover marker osteocalcin upon admission for hip fracture and in healthy controls. RESULTS: Vitamin K1 and 25(OH)D were independently associated with a risk of hip fracture. The adjusted odds ratio (95% CI) per ng/ml increase in vitamin K1 was 0.07 (0.02-0.32), and that per nmol/L increase in 25(OH)D was 0.96 (0.95-0.98). There was a significant interaction between 25(OH)D and vitamin K1 (p < 0.001), and a significant correlation between total osteocalcin and vitamin K1 and 25(OH)D (rho = 0.18, p = 0.01; rho = 0.20, p = 0.01, respectively). CONCLUSIONS: Vitamin K1 and 25(OH)D are lower in hip fracturepatients compared with controls. Vitamin K1 and 25(OH)D are independently and synergistically associated with the risk of hip fracture when adjusting for confounders. Intervention studies should include both vitamins. Crown
Authors: Kevin D Cashman; Ellen Ghm van den Heuvel; Ruud Jw Schoemaker; Damien P Prévéraud; Helen M Macdonald; Jayashree Arcot Journal: Adv Nutr Date: 2017-11-15 Impact factor: 8.701
Authors: Adriana J van Ballegooijen; Stefan Pilz; Andreas Tomaschitz; Martin R Grübler; Nicolas Verheyen Journal: Int J Endocrinol Date: 2017-09-12 Impact factor: 3.257
Authors: Maria Fusaro; Luca Dalle Carbonare; Adriana Dusso; Maria Vittoria Arcidiacono; Maria Teresa Valenti; Andrea Aghi; Sabina Pasho; Maurizio Gallieni Journal: PLoS One Date: 2015-08-04 Impact factor: 3.240