| Literature DB >> 24559087 |
Xing-Rong Peng1, Jie-Qing Liu, Cui-Fang Wang, Xu-Yang Li, Yi Shu, Lin Zhou, Ming-Hua Qiu.
Abstract
Two novel trinorlanostanes, cochlates A and B (1 and 2), with a 3,4-seco-9,10-seco-9,19-cyclo skeleton, as well as six new triterpenoids, fornicatins D-F (3-5) and ganodercochlearins A-C (6-8), together with five known triterpenoids (9-13), were obtained from the fruiting bodies of Ganoderma cochlear. The structural elucidation was achieved by interpretation of spectroscopic data, and compounds 2 and 7a were further characterized by X-ray crystallographic analysis. Fornicatins A, D, and F (10, 3, and 5) and fredelin (13) lowered the ALT and AST levels in HepG2 cells treated with H2O2, suggesting that they could display in vivo hepatoprotective activities.Entities:
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Year: 2014 PMID： 24559087 DOI： 10.1021/np400323u
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050