Paola Vanessa Miranda Alatriste1, Rocío Urbina Arronte2, Cristóbal Obet Gómez Espinosa2, María de los Ángeles Espinosa Cuevas1. 1. Departamento de Nefrología y Metabolismo Mineral. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. México D. F. Departamento de Atención a la Salud. Universidad Autónoma Metropolitana. Xochimilco. México D. F.. angespinosac@gmail.com. 2. Departamento de Atención a la Salud. Universidad Autónoma Metropolitana. Xochimilco. México D. F..
Abstract
INTRODUCTION:Patients with chronic kidney disease (CKD) show an increase in bowel aerobic bacteria that produce uremic toxins and decreased anaerobic bacteria as bifidobacteria and lactobacillus. The latter can be used as probiotics. The probiotic with greater availability in Mexico, is the lactobacillus casei shirota (LcS), currently there is no known LcS specified dose that produces a benefit to the patient with CKD. OBJECTIVE: To determine the effectiveness of two different LcS doses in achieving a decrease in urea concentrations of at least 10% in patients with KDOQI stage 3 and stage 4 CKD. METODOLOGY: A simple randomized, controlled clinical trial. Outpatients treated at the National Institute of Medical Sciences and Nutrition Salvador Zubirán in México D.F. Patients were provided the LcS, as follows: Group A: 8 x 10(9) colony-forming units (CFU) and Group B: 16 x 10(9) CFU. Patients were followed-up for eight weeks, and baseline and final samples were obtained to calculate the basal and final concentrations, respectively, of blood urea and serum creatinine (CrS). During the follow-up, both groups consumed a diet of 30 kcal/kg/weight and 0.8 g/kg/weight of protein, and a food diary was made to assess both the adherence to the diet and LcS. RESULTS:Thirty patients with CKD were evaluated. When analyzing the percentage change between the different doses, a decrease > 10% was found in the blood urea concentrations for patients treated with the 16 x 109 dose, which was significant with respect to the baseline measurement. CONCLUSION: There was a > 10% decrease in the serum urea concentrations with LcS in patients with stage 3 and 4 CRF. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
RCT Entities:
INTRODUCTION:Patients with chronic kidney disease (CKD) show an increase in bowel aerobic bacteria that produce uremic toxins and decreased anaerobic bacteria as bifidobacteria and lactobacillus. The latter can be used as probiotics. The probiotic with greater availability in Mexico, is the lactobacillus casei shirota (LcS), currently there is no known LcS specified dose that produces a benefit to the patient with CKD. OBJECTIVE: To determine the effectiveness of two different LcS doses in achieving a decrease in urea concentrations of at least 10% in patients with KDOQI stage 3 and stage 4 CKD. METODOLOGY: A simple randomized, controlled clinical trial. Outpatients treated at the National Institute of Medical Sciences and Nutrition Salvador Zubirán in México D.F. Patients were provided the LcS, as follows: Group A: 8 x 10(9) colony-forming units (CFU) and Group B: 16 x 10(9) CFU. Patients were followed-up for eight weeks, and baseline and final samples were obtained to calculate the basal and final concentrations, respectively, of blood urea and serum creatinine (CrS). During the follow-up, both groups consumed a diet of 30 kcal/kg/weight and 0.8 g/kg/weight of protein, and a food diary was made to assess both the adherence to the diet and LcS. RESULTS: Thirty patients with CKD were evaluated. When analyzing the percentage change between the different doses, a decrease > 10% was found in the blood urea concentrations for patients treated with the 16 x 109 dose, which was significant with respect to the baseline measurement. CONCLUSION: There was a > 10% decrease in the serum urea concentrations with LcS in patients with stage 3 and 4 CRF. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
Authors: Mehmet Kanbay; Emine M Onal; Baris Afsar; Tuncay Dagel; Aslihan Yerlikaya; Adrian Covic; Nosratola D Vaziri Journal: Int Urol Nephrol Date: 2018-05-04 Impact factor: 2.370