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Literature DB >> 2455873

Acute reduction of brain substance P induced by nicotine.

N E Naftchi¹, H Maker, E Lapin, J Sleis, A Lajtha, S Leeman.

Abstract

Ten minutes after a single injection of 0.8 mg/kg nicotine SC (free base) the level of substance P-like immunoreactivity (SPLI) was reduced by 61-73% in rat caudate-putamen, nucleus accumbens, and olfactory tubercle, with smaller and not significant reductions in the frontal cortex, substantia nigra, and ventral tegmental area. The nicotinic receptor antagonist mecamylamine (1.0 mg/kg IP) prevented the reductions in SPLI. The rapidity and the degree of the changes in SPLI after nicotine exceed those previously reported for other agents and implicate substance P neurotransmission as a major component of nicotinic action.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1988 PMID： 2455873 DOI： 10.1007/bf00972478

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

37 in total

1. Substance P in the substantia nigra.

Authors: J Davies; A Dray
Journal: Brain Res Date: 1976-05-14 Impact factor: 3.252

2. Regional distribution of substance P in the brain of the rat.

Authors: M J Brownstein; E A Mroz; J S Kizer; M Palkovits; S E Leeman
Journal: Brain Res Date: 1976-11-05 Impact factor: 3.252

3. Rotatory behavior in rats by intranigral application of substance P and an eledoisin fragment.

Authors: H R Olpe; W P Koella
Journal: Brain Res Date: 1977-05-13 Impact factor: 3.252

4. Behavioral analysis of the effect of substance P injected into the ventral mesencephalon on investigatory and spontaneous motor behavior in the rat.

Authors: A E Kelley; M Cador; L Stinus
Journal: Psychopharmacology (Berl) Date: 1985 Impact factor: 4.530

Review 5. The striatonigral substance P pathway and dopaminergic mechanisms.

Authors: J Glowinski; Y Torrens; J C Beaujouan
Journal: Ciba Found Symp Date: 1982

6. Smoking and Parkinson's disease.

Authors: R B Godwin-Austen; P N Lee; M G Marmot; G M Stern
Journal: J Neurol Neurosurg Psychiatry Date: 1982-07 Impact factor: 10.154

7. Effects of single injections of nicotine on the ascending dopamine pathways in the rat. Evidence for increases of dopamine turnover in the mesostriatal and mesolimbic dopamine neurons.

Authors: K Andersson; K Fuxe; L F Agnati
Journal: Acta Physiol Scand Date: 1981-07

8. Differential effects of mecamylamine on the nicotine induced changes in amine levels and turnover in hypothalamic dopamine and noradrenaline nerve terminal systems and in the secretion of adenohypophyseal hormones in the castrated female rat. Evidence for involvement of cholinergic nicotine-like receptors.

Authors: K Anderson; K Fuxe; P Eneroth; L F Agnati
Journal: Acta Physiol Scand Date: 1984-04

9. Dopamine-like action of nicotine: lack of tolerance and reverse tolerance.

Authors: E P Lapin; H S Maker; H Sershen; Y Hurd; A Lajtha
Journal: Brain Res Date: 1987-03-31 Impact factor: 3.252

10. Actions of substance P, MIF, TRH and related peptides in the substantia nigra, caudate nucleus and nucleus accumbens.

Authors: R D Pinnock; G N Woodruff; M J Turnbull
Journal: Neuropharmacology Date: 1983-06 Impact factor: 5.250

5 in total

Acute reduction of brain substance P induced by nicotine.

1. Substance P in the substantia nigra.

2. Regional distribution of substance P in the brain of the rat.

3. Rotatory behavior in rats by intranigral application of substance P and an eledoisin fragment.

4. Behavioral analysis of the effect of substance P injected into the ventral mesencephalon on investigatory and spontaneous motor behavior in the rat.

Review 5. The striatonigral substance P pathway and dopaminergic mechanisms.

6. Smoking and Parkinson's disease.

7. Effects of single injections of nicotine on the ascending dopamine pathways in the rat. Evidence for increases of dopamine turnover in the mesostriatal and mesolimbic dopamine neurons.

9. Dopamine-like action of nicotine: lack of tolerance and reverse tolerance.

10. Actions of substance P, MIF, TRH and related peptides in the substantia nigra, caudate nucleus and nucleus accumbens.

1. Interactions between tachykinins and diverse, human nicotinic acetylcholine receptor subtypes.

2. Modulation of nicotine-induced analgesia by calcium agonist and antagonist in adult rats.

3. Nicotinic and dopamine D2 receptors mediate nicotine-induced changes in ventral tegmental area neurotensin system.

4. Responses of limbic and extrapyramidal substance P systems to nicotine treatment.

5. Sex differences in neurotensin and substance P following nicotine self-administration in rats.