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Literature DB >> 24558645

Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer.

Minkyu Kim¹, Manos Gkikas, Aaron Huang, Jeon Woong Kang, Nisaraporn Suthiwangcharoen, Ramanathan Nagarajan, Bradley D Olsen.

Abstract

A simple approach to enhancing the activity and stability of organophosphorus hydrolase (OPH) is developed based on interactions between the hydrophobic poly(propylene oxide) (PPO) block of amphiphilic Pluronics and the enzyme. This strategy provides an efficient route to new formulations for decontaminating organophosphate neurotoxins.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2014 PMID： 24558645 PMCID： PMC4059822 DOI： 10.1039/c3cc47675h

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

26 in total

1. Biocatalytic nerve agent detoxification in fire fighting foams.

Authors: K E LeJeune; A J Russell
Journal: Biotechnol Bioeng Date: 1999-03-20 Impact factor: 4.530

2. Entrapping enzyme in a functionalized nanoporous support.

Authors: Chenghong Lei; Yongsoon Shin; Jun Liu; Eric J Ackerman
Journal: J Am Chem Soc Date: 2002-09-25 Impact factor: 15.419

Review 3. Stabilization of proteins for storage.

Authors: Richard J Simpson
Journal: Cold Spring Harb Protoc Date: 2010-05

4. Detoxification of the organophosphate nerve agent coumaphos using organophosphorus hydrolase immobilized on cellulose materials.

Authors: Ayman H Mansee; Wilfred Chen; Ashok Mulchandani
Journal: J Ind Microbiol Biotechnol Date: 2005-11-15 Impact factor: 3.346

5. Construction of robust enzyme nanocapsules for effective organophosphate decontamination, detoxification, and protection.

Authors: Wei Wei; Juanjuan Du; Jie Li; Ming Yan; Qi Zhu; Xin Jin; Xinyuan Zhu; Zuming Hu; Yi Tang; Yunfeng Lu
Journal: Adv Mater Date: 2013-02-25 Impact factor: 30.849

6. Improved pharmacokinetics and immunogenicity profile of organophosphorus hydrolase by chemical modification with polyethylene glycol.

Authors: Boris N Novikov; Janet K Grimsley; Rory J Kern; James R Wild; Melinda E Wales
Journal: J Control Release Date: 2010-06-11 Impact factor: 9.776

7. Metal-substrate interactions facilitate the catalytic activity of the bacterial phosphotriesterase.

Authors: S B Hong; F M Raushel
Journal: Biochemistry Date: 1996-08-20 Impact factor: 3.162

8. His6-OPH enzyme-based bio-hybrid material for organophosphate detection.

Authors: Nina Frančič; Aljoša Košak; Ilya Lyagin; Elena N Efremenko; Aleksandra Lobnik
Journal: Anal Bioanal Chem Date: 2011-08-28 Impact factor: 4.142

Review 9. Microbial degradation of organophosphorus compounds.

Authors: Brajesh K Singh; Allan Walker
Journal: FEMS Microbiol Rev Date: 2006-05 Impact factor: 16.408

10. Stabilization of organophosphorus hydrolase by entrapment in silk fibroin: formation of a robust enzymatic material suitable for surface coatings.

Authors: Patrick B Dennis; Anne Y Walker; Matthew B Dickerson; David L Kaplan; Rajesh R Naik
Journal: Biomacromolecules Date: 2012-06-12 Impact factor: 6.988

4 in total

Review 1. Organophosphate-Hydrolyzing Enzymes as First-Line of Defence Against Nerve Agent-Poisoning: Perspectives and the Road Ahead.

Authors: A R Satvik Iyengar; Abhay H Pande
Journal: Protein J Date: 2016-12 Impact factor: 2.371