Heike M Elflein1, Norbert Pfeiffer, Esther M Hoffmann, René Hoehn, Ulrike Kottler, Katrin Lorenz, Isabella Zwiener, Philipp S Wild, Alireza Mirshahi. 1. *Department of Ophthalmology, University Medical Center Mainz, Johannes Gutenberg University Mainz, Germany; †Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, Johannes Gutenberg University Mainz, Germany; and ‡Department of Medicine II, University Medical Center Mainz, Johannes Gutenberg University Mainz, Germany.
Abstract
PURPOSE: The aim of this study was to evaluate the correlations between general anthropometric features and cardiovascular parameters and central corneal thickness (CCT) in an adult European cohort. METHODS: Analysis was based on a Gutenberg Health Study cohort that included 5000 subjects (2540 male, 2460 female), aged 35 to 74 years at enrollment. The participants underwent a standardized protocol with a comprehensive questionnaire; ophthalmic examination (slit-lamp biomicroscopy; autorefractometry; noncontact tonometry; fundus photography; CCT measurements (optical pachymetry); visual field testing; and a thorough general examination focused on cardiovascular parameters, psychosomatic evaluation, and laboratory tests including genetic analysis. RESULTS: Reliable CCT measurements were available for 4708 right eyes (OD, 94.2%), 4721 left eyes (OS, 94.4%), and both eyes (OU) in 4698 subjects (94.0%). The mean CCT was 555 ± 35 μm in men and 549 ± 35 μm in women. In multiple linear regression analysis, the CCT was associated with gender [P < 0.001 for OU], body height [in men, P = 0.007 for OD, P = 0.04 for OS; in women P < 0.001 for OU], and body mass index (P < 0.001 for OD, P = 0.001 for OS). In men only, the CCT correlated with the body weight [P = 0.024 (OD), P = 0.048 (OS)] and smoking [P = 0.006 (OD), P < 0.001 (OS)]. No correlations were found between the CCT and dyslipidemia, diabetes, or hypertension. CONCLUSIONS: The CCT was associated with male gender, body height, and body mass index in an adult white cohort. It correlated with body weight and nicotine abuse in men only. No associations were found between the CCT and dyslipidemia, diabetes, or hypertension.
PURPOSE: The aim of this study was to evaluate the correlations between general anthropometric features and cardiovascular parameters and central corneal thickness (CCT) in an adult European cohort. METHODS: Analysis was based on a Gutenberg Health Study cohort that included 5000 subjects (2540 male, 2460 female), aged 35 to 74 years at enrollment. The participants underwent a standardized protocol with a comprehensive questionnaire; ophthalmic examination (slit-lamp biomicroscopy; autorefractometry; noncontact tonometry; fundus photography; CCT measurements (optical pachymetry); visual field testing; and a thorough general examination focused on cardiovascular parameters, psychosomatic evaluation, and laboratory tests including genetic analysis. RESULTS: Reliable CCT measurements were available for 4708 right eyes (OD, 94.2%), 4721 left eyes (OS, 94.4%), and both eyes (OU) in 4698 subjects (94.0%). The mean CCT was 555 ± 35 μm in men and 549 ± 35 μm in women. In multiple linear regression analysis, the CCT was associated with gender [P < 0.001 for OU], body height [in men, P = 0.007 for OD, P = 0.04 for OS; in women P < 0.001 for OU], and body mass index (P < 0.001 for OD, P = 0.001 for OS). In men only, the CCT correlated with the body weight [P = 0.024 (OD), P = 0.048 (OS)] and smoking [P = 0.006 (OD), P < 0.001 (OS)]. No correlations were found between the CCT and dyslipidemia, diabetes, or hypertension. CONCLUSIONS: The CCT was associated with male gender, body height, and body mass index in an adult white cohort. It correlated with body weight and nicotine abuse in men only. No associations were found between the CCT and dyslipidemia, diabetes, or hypertension.
Authors: João N Beato; João Esteves-Leandro; David Reis; Manuel Falcão; Vítor Rosas; Ângela Carneiro; Fernando Falcão Reis Journal: Clin Ophthalmol Date: 2020-07-14
Authors: Reza Soleimanizad; Mohammad Hosein Nowroozzadeh; Hossein Ziaei; Mohammad Pakravan; Mehdi Yaseri; Marzieh Katibeh Journal: J Ophthalmic Vis Res Date: 2017 Apr-Jun